(3S,5S,6R)-2-Oxo-3-[2-(2S)-2-oxiranylethyl]-5,6-diphenyl-4-Morpholinecarboxylic Acid tert-Butyl Ester

Base Information

Chemical Name:(3S,5S,6R)-2-Oxo-3-[2-(2S)-2-oxiranylethyl]-5,6-diphenyl-4-Morpholinecarboxylic Acid tert-Butyl Ester
CAS No.:753010-15-0
Molecular Formula:C₂₅H₂₉NO₅
Molecular Weight:423.509
Hs Code.:
Mol file:753010-15-0.mol

Synonyms:tert-butyl (3S,5S,6R)-3-[(3S)-3,4-epoxybutyl]-2-oxo-5,6-diphenyl-1,4-oxazinane-4-carboxylate

Suppliers and Price of (3S,5S,6R)-2-Oxo-3-[2-(2S)-2-oxiranylethyl]-5,6-diphenyl-4-Morpholinecarboxylic Acid tert-Butyl Ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(3S,5S,6R)-2-Oxo-3-[2-(2S)-2-oxiranylethyl]-5,6-diphenyl-4-morpholinecarboxylicAcidtert-ButylEster
100mg
$ 1320.00

TRC
(3S,5S,6R)-2-Oxo-3-[2-(2S)-2-oxiranylethyl]-5,6-diphenyl-4-morpholinecarboxylicAcidtert-ButylEster
10mg
$ 165.00

Medical Isotopes, Inc.
(3S,5S,6R)-2-Oxo-3-[2-(2S)-2-oxiranylethyl]-5,6-diphenyl-4-morpholinecarboxylicAcidtert-ButylEster
100 mg
$ 2200.00

Medical Isotopes, Inc.
(3S,5S,6R)-2-Oxo-3-[2-(2S)-2-oxiranylethyl]-5,6-diphenyl-4-morpholinecarboxylicAcidtert-ButylEster
10 mg
$ 650.00

Total 0 raw suppliers

Chemical Property of (3S,5S,6R)-2-Oxo-3-[2-(2S)-2-oxiranylethyl]-5,6-diphenyl-4-Morpholinecarboxylic Acid tert-Butyl Ester

Chemical Property:

Melting Point:125-127 °C
Boiling Point:577.6±50.0 °C(Predicted)
PKA:-3.34±0.70(Predicted)
Density:1.181±0.06 g/cm3(Predicted)
Solubility.:Dichloromethane

Purity/Quality:: (3S,5S,6R)-2-Oxo-3-[2-(2S)-2-oxiranylethyl]-5,6-diphenyl-4-morpholinecarboxylicAcidtert-ButylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses (3S,5S,6R)-2-Oxo-3-[2-(2S)-2-oxiranylethyl]-5,6-diphenyl-4-morpholinecarboxylic Acid tert-Butyl Ester is a reactant used in the preparation of enantiopure stereoisomers of hydroxylysinonorleucine and dihydroxylysinonorleucine (D452900) as reduced collagen cross link.

Technology Process of (3S,5S,6R)-2-Oxo-3-[2-(2S)-2-oxiranylethyl]-5,6-diphenyl-4-Morpholinecarboxylic Acid tert-Butyl Ester

There total 2 articles about (3S,5S,6R)-2-Oxo-3-[2-(2S)-2-oxiranylethyl]-5,6-diphenyl-4-Morpholinecarboxylic Acid tert-Butyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 869111-54-6
tert-butyl (3S,5S,6R)-3-[(3S)-3-hydroxy-4-bromo-butyl]-2-oxo-5,6-diphenyl-1,4-oxazinane-4-carboxylate

: 753010-15-0
tert-butyl (3S,5S,6R)-3-[(3S)-3,4-epoxybutyl]-2-oxo-5,6-diphenyl-1,4-oxazinane-4-carboxylate

Guidance literature:: With CsCO₃; In acetonitrile; at 20 ℃; for 2h;
DOI:10.1016/j.tetasy.2005.08.023

Reference yield:

: 937183-38-5
tert-butyl (3S,5S,6R)-3-(2-((RS)oxiran-2-yl)ethyl)-2-oxo-5,6-diphenylmorpholine-4-carboxylate

: 753010-15-0
tert-butyl (3S,5S,6R)-3-[(3S)-3,4-epoxybutyl]-2-oxo-5,6-diphenyl-1,4-oxazinane-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 41 percent / anhydrous lithium bromide; AcOH / tetrahydrofuran / 4 h / 20 °C

2: 92 percent / CsCO₃ / acetonitrile / 2 h / 20 °C

With acetic acid; lithium bromide; In tetrahydrofuran; acetonitrile;
DOI:10.1016/j.tetasy.2005.08.023