2,4-bis(benzyloxy)-5-1-[(3,5-di-O-benzyl-2-deoxy-β-D-ribofuranosyl)-1H-imidazol-4-yl]pyrimidine

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Chemical Name:2,4-bis(benzyloxy)-5-1-[(3,5-di-O-benzyl-2-deoxy-β-D-ribofuranosyl)-1H-imidazol-4-yl]pyrimidine
CAS No.:1418269-03-0
Molecular Formula:C₄₀H₃₈N₄O₅
Molecular Weight:654.766
Hs Code.:

Synonyms:2,4-bis(benzyloxy)-5-1-[(3,5-di-O-benzyl-2-deoxy-β-D-ribofuranosyl)-1H-imidazol-4-yl]pyrimidine

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Chemical Property of 2,4-bis(benzyloxy)-5-1-[(3,5-di-O-benzyl-2-deoxy-β-D-ribofuranosyl)-1H-imidazol-4-yl]pyrimidine

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Technology Process of 2,4-bis(benzyloxy)-5-1-[(3,5-di-O-benzyl-2-deoxy-β-D-ribofuranosyl)-1H-imidazol-4-yl]pyrimidine

There total 4 articles about 2,4-bis(benzyloxy)-5-1-[(3,5-di-O-benzyl-2-deoxy-β-D-ribofuranosyl)-1H-imidazol-4-yl]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1418268-90-2
1-[3,5-di-O-benzyl-2-deoxy-β-D-ribofuranosyl]-4-iodo-1H-imidazole

: 70523-24-9
5-(dihydroxyboryl)-2,4-bis(benzyloxy)pyrimidine

: 1418269-03-0
2,4-bis(benzyloxy)-5-1-[(3,5-di-O-benzyl-2-deoxy-β-D-ribofuranosyl)-1H-imidazol-4-yl]pyrimidine

Guidance literature:: 1-[3,5-di-O-benzyl-2-deoxy-β-D-ribofuranosyl]-4-iodo-1H-imidazole; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; at 20 ℃; for 0.166667h; Inert atmosphere;

5-(dihydroxyboryl)-2,4-bis(benzyloxy)pyrimidine; With sodium hydrogencarbonate; In 1,2-dimethoxyethane; water; for 4h; Reflux; Inert atmosphere;
DOI:10.1055/s-0032-1316791

Reference yield:

: 909869-57-4
1-(2-deoxy-β-D-ribofuranos-1-yl)-4,5-diiodoimidazole

: 1418269-03-0
2,4-bis(benzyloxy)-5-1-[(3,5-di-O-benzyl-2-deoxy-β-D-ribofuranosyl)-1H-imidazol-4-yl]pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran

2.1: ethylmagnesium bromide / tetrahydrofuran / 3 h / 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 0.17 h / 20 °C / Inert atmosphere

3.2: 4 h / Reflux; Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; ethylmagnesium bromide; sodium hydride; In tetrahydrofuran; 1,2-dimethoxyethane;
DOI:10.1055/s-0032-1316791

Reference yield:

: 100-39-0
benzyl bromide

: 1418269-03-0
2,4-bis(benzyloxy)-5-1-[(3,5-di-O-benzyl-2-deoxy-β-D-ribofuranosyl)-1H-imidazol-4-yl]pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran

2.1: ethylmagnesium bromide / tetrahydrofuran / 3 h / 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 0.17 h / 20 °C / Inert atmosphere

3.2: 4 h / Reflux; Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; ethylmagnesium bromide; sodium hydride; In tetrahydrofuran; 1,2-dimethoxyethane;
DOI:10.1055/s-0032-1316791