3-iodo-6-isopropoxy-2-(3'-isopropoxy-4'-methoxyphenyl)-5-methoxybenzofuran

Base Information

Chemical Name:3-iodo-6-isopropoxy-2-(3'-isopropoxy-4'-methoxyphenyl)-5-methoxybenzofuran
CAS No.:218903-35-6
Molecular Formula:C₂₂H₂₅IO₅
Molecular Weight:496.342
Hs Code.:

Synonyms:3-iodo-6-isopropoxy-2-(3'-isopropoxy-4'-methoxyphenyl)-5-methoxybenzofuran

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Chemical Property of 3-iodo-6-isopropoxy-2-(3'-isopropoxy-4'-methoxyphenyl)-5-methoxybenzofuran

Chemical Property:

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Technology Process of 3-iodo-6-isopropoxy-2-(3'-isopropoxy-4'-methoxyphenyl)-5-methoxybenzofuran

There total 6 articles about 3-iodo-6-isopropoxy-2-(3'-isopropoxy-4'-methoxyphenyl)-5-methoxybenzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 215715-45-0
5-isopropoxy-2-[2'-(3''-isopropoxy-4''-methoxyphenyl)ethynyl]-4-methoxyphenol

: 218903-35-6
3-iodo-6-isopropoxy-2-(3'-isopropoxy-4'-methoxyphenyl)-5-methoxybenzofuran

Guidance literature:: With N-iodo-succinimide; In N,N-dimethyl-formamide; at 18 ℃; for 1h;
DOI:10.1071/CH99022

Reference yield:

: 34123-66-5
O-isopropylisovanillin

: 218903-35-6
3-iodo-6-isopropoxy-2-(3'-isopropoxy-4'-methoxyphenyl)-5-methoxybenzofuran

Guidance literature:: Multi-step reaction with 5 steps

1.1: 93 percent / I₂; AgOCOCF₃ / CHCl₃ / 6.5 h / Heating

2.1: 2.5 M BuLi / hexane; tetrahydrofuran / 0.5 h / -78 °C

2.2: ZnCl₂ / hexane; tetrahydrofuran / -78 - 18 °C

2.3: 92 percent / PdCl₂(PPh₃)2 / hexane; tetrahydrofuran / 6 h / 18 °C

3.1: m-chloroperbenzoic acid; KHCO₃ / CH₂Cl₂ / 1 h / 0 - 18 °C

4.1: NH₃ / methanol / 1 h / 18 °C

5.1: 99 percent / N-iodosuccinimide / dimethylformamide / 1 h / 18 °C

With N-iodo-succinimide; n-butyllithium; ammonia; iodine; silver trifluoroacetate; potassium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; hexane; dichloromethane; chloroform; N,N-dimethyl-formamide; 1.1: Iodination / 2.1: Elimination / 2.2: transmetallation / 2.3: Negishi cross-coupling / 3.1: Baeyer-Villiger oxidation / 4.1: Hydrolysis / 5.1: 5-endo-dig iodocyclization;
DOI:10.1071/CH99022

Reference yield:

: 200941-15-7
2-iodo-5-isopropoxy-4-methoxybenzaldehyde

: 218903-35-6
3-iodo-6-isopropoxy-2-(3'-isopropoxy-4'-methoxyphenyl)-5-methoxybenzofuran

Guidance literature:: Multi-step reaction with 4 steps

1.1: 2.5 M BuLi / hexane; tetrahydrofuran / 0.5 h / -78 °C

1.2: ZnCl₂ / hexane; tetrahydrofuran / -78 - 18 °C

1.3: 92 percent / PdCl₂(PPh₃)2 / hexane; tetrahydrofuran / 6 h / 18 °C

2.1: m-chloroperbenzoic acid; KHCO₃ / CH₂Cl₂ / 1 h / 0 - 18 °C

3.1: NH₃ / methanol / 1 h / 18 °C

4.1: 99 percent / N-iodosuccinimide / dimethylformamide / 1 h / 18 °C

With N-iodo-succinimide; n-butyllithium; ammonia; potassium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; 1.1: Elimination / 1.2: transmetallation / 1.3: Negishi cross-coupling / 2.1: Baeyer-Villiger oxidation / 3.1: Hydrolysis / 4.1: 5-endo-dig iodocyclization;
DOI:10.1071/CH99022