5-isopropoxy-2-[2'-(3''-isopropoxy-4''-methoxyphenyl)ethynyl]-4-methoxyphenol

Base Information

• Chemical Name: 5-isopropoxy-2-[2'-(3''-isopropoxy-4''-methoxyphenyl)ethynyl]-4-methoxyphenol
• CAS No.: 215715-45-0
• Molecular Formula: C₂₂H₂₆O₅
• Molecular Weight: 370.445
• Mol file: 215715-45-0.mol

Synonyms:5-isopropoxy-2-[2'-(3''-isopropoxy-4''-methoxyphenyl)ethynyl]-4-methoxyphenol

Chemical Property of 5-isopropoxy-2-[2'-(3''-isopropoxy-4''-methoxyphenyl)ethynyl]-4-methoxyphenol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-isopropoxy-2-[2'-(3''-isopropoxy-4''-methoxyphenyl)ethynyl]-4-methoxyphenol

There total 7 articles about 5-isopropoxy-2-[2'-(3''-isopropoxy-4''-methoxyphenyl)ethynyl]-4-methoxyphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

formic acid 5-isopropoxy-2-(3-isopropoxy-4-methoxy-phenylethynyl)-4-methoxy-phenyl ester (475232-31-6) → 5-isopropoxy-2-[2'-(3''-isopropoxy-4''-methoxyphenyl)ethynyl]-4-methoxyphenol (215715-45-0)

Guidance literature:

With ammonia; In methanol; dichloromethane; at 20 ℃; for 2h;

DOI:10.1016/S0968-0896(02)00237-7

Reference yield:

O-isopropylisovanillin (34123-66-5) → 5-isopropoxy-2-[2'-(3''-isopropoxy-4''-methoxyphenyl)ethynyl]-4-methoxyphenol (215715-45-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 95 percent / silver trifluoroacetate; iodine / CH₂Cl₂ / 12 h / Heating

2: 66 percent / CuI; Et₃N / Pd(PPh₃)4 / 5 h / 45 °C

3: 89 percent / 3-chloroperoxybenzoic acid; KHCO₃ / CH₂Cl₂ / 1 h / 20 °C

4: 98 percent / NH₃ / methanol; CH₂Cl₂ / 2 h / 20 °C

With copper(l) iodide; ammonia; iodine; silver trifluoroacetate; potassium hydrogencarbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; dichloromethane;

DOI:10.1016/S0968-0896(02)00237-7

Reference yield:

2-iodo-5-isopropoxy-4-methoxybenzaldehyde (200941-15-7) → 5-isopropoxy-2-[2'-(3''-isopropoxy-4''-methoxyphenyl)ethynyl]-4-methoxyphenol (215715-45-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 66 percent / CuI; Et₃N / Pd(PPh₃)4 / 5 h / 45 °C

2: 89 percent / 3-chloroperoxybenzoic acid; KHCO₃ / CH₂Cl₂ / 1 h / 20 °C

3: 98 percent / NH₃ / methanol; CH₂Cl₂ / 2 h / 20 °C

With copper(l) iodide; ammonia; potassium hydrogencarbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; dichloromethane;

DOI:10.1016/S0968-0896(02)00237-7

upstream raw materials:

formic acid 5-isopropoxy-2-(3-isopropoxy-4-methoxy-phenylethynyl)-4-methoxy-phenyl ester

isovanillin

O-isopropylisovanillin

2-iodo-5-isopropoxy-4-methoxybenzaldehyde

Downstream raw materials:

3-iodo-6-isopropoxy-2-(3'-isopropoxy-4'-methoxyphenyl)-5-methoxybenzofuran

1-(α-Iodoacetoxy)-2-[(3-isopropoxy-4-methoxy-phenyl)ethynyl]-5-isopropoxy-4-methoxybenzene

14-(3,4-dihydroxyphenyl)-2,3,11,12-tetrahydroxy-6H-chromeno[4′,3′:4,5]pyrrolo[2,1-a]isoquinolin-6-one

3-hydroxy-14-(3-hydroxy-4-methoxyphenyl)-2,11,12-trimethoxy-6H-[1]benzopyrano[4',3':4,5]-pyrrolo[2,1-a]isoquinolin-6-one