1-Benzyl-8-methylsulfanyl-6-phenyl-4H-2,3,5,10b-tetraaza-benzo[e]azulene

Base Information

• Chemical Name: 1-Benzyl-8-methylsulfanyl-6-phenyl-4H-2,3,5,10b-tetraaza-benzo[e]azulene
• CAS No.: 119794-22-8
• Molecular Formula: C₂₄H₂₀N₄S
• Molecular Weight: 396.516
• Mol file: 119794-22-8.mol

Synonyms:1-Benzyl-8-methylsulfanyl-6-phenyl-4H-2,3,5,10b-tetraaza-benzo[e]azulene

Chemical Property of 1-Benzyl-8-methylsulfanyl-6-phenyl-4H-2,3,5,10b-tetraaza-benzo[e]azulene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Benzyl-8-methylsulfanyl-6-phenyl-4H-2,3,5,10b-tetraaza-benzo[e]azulene

There total 1 articles about 1-Benzyl-8-methylsulfanyl-6-phenyl-4H-2,3,5,10b-tetraaza-benzo[e]azulene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.6%

1,3-dihydro-7-(methylthio)-5-phenyl-2H-1,4-benzodiazepine-2-thione (35628-45-6) + 2-phenylacetylhydrazine (937-39-3) → 1-Benzyl-8-methylsulfanyl-6-phenyl-4H-2,3,5,10b-tetraaza-benzo[e]azulene (119794-22-8)

Guidance literature:

In butan-1-ol; Heating;

DOI:10.1021/jm00126a003

Reference yield: 73.3%

1-Benzyl-8-methylsulfanyl-6-phenyl-4H-2,3,5,10b-tetraaza-benzo[e]azulene (119794-22-8) → 8-(methylsulfonyl)-6-phenyl-1-(phenylmethyl)-4H-<1,2,4>triazolo<4,3-a><1,4>benzodiazepine (119794-21-7)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; 1.) 0 deg C to r.t., 1 h, 2.) r.t., 7 h;

DOI:10.1021/jm00126a003

Reference yield: 61.6%

bis-(dimethylamino)methane (51-80-9) + 1-Benzyl-8-methylsulfanyl-6-phenyl-4H-2,3,5,10b-tetraaza-benzo[e]azulene (119794-22-8) → N,N-dimethyl-8-(methylthio)-β,6-diphenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-1-ethanamine

Guidance literature:

With acetyl chloride; In N,N-dimethyl-formamide; at 0 ℃;

DOI:10.1021/jm00126a003

upstream raw materials:

1,3-dihydro-7-(methylthio)-5-phenyl-2H-1,4-benzodiazepine-2-thione

2-phenylacetylhydrazine

Downstream raw materials:

8-(methylsulfonyl)-6-phenyl-1-(phenylmethyl)-4H-<1,2,4>triazolo<4,3-a><1,4>benzodiazepine