N,N,N',N'-Tetramethylmethanediamine

Base Information

• Chemical Name: N,N,N',N'-Tetramethylmethanediamine
• CAS No.: 51-80-9
• Deprecated CAS: 102830-06-8,29572-95-0,29572-95-0
• Molecular Formula: C5H14 N2
• Molecular Weight: 102.18
• Hs Code.: 29212900
• European Community (EC) Number: 200-124-7
• NSC Number: 166169,54796
• UN Number: 1993
• UNII: Z870I525KS
• DSSTox Substance ID: DTXSID1058761
• Nikkaji Number: J48.656F
• Wikipedia: Bis(dimethylamino)methane
• Wikidata: Q27295126
• Mol file: 51-80-9.mol

Synonyms:51-80-9;N,N,N',N'-Tetramethylmethanediamine;N,N,N',N'-Tetramethyldiaminomethane;Bis(dimethylamino)methane;Tetramethylmethylenediamine;METHANEDIAMINE, N,N,N',N'-TETRAMETHYL-;Methylenebis(dimethylamine);[(dimethylamino)methyl]dimethylamine;Dimethyl((dimethylamino)methyl)amine;102830-06-8;N,N,N',N'-Tetramethylmethylenediamine;NSC 166169;Methylenediamine, N,N,N',N'-tetramethyl-;N,N,N',N'-Tetramethyldiaminomethan;EINECS 200-124-7;UNII-Z870I525KS;AI3-26640;N,N,N',N'-Tetramethyldiaminomethan [German];n,n,n,n-tetramethyldiaminomethane;Z870I525KS;Dimethyl[(dimethylamino)methyl]amine;NSC-54796;NSC-166169;EC 200-124-7;Tetramethyl methylene diamine;N,N',N'-Tetramethyldiaminomethan;N,N',N'-Tetramethylmethanediamine;N,N',N'-Tetramethylmethylenediamine;WLN: 1N1&1N1&1;Methanediamine,N,N',N'-tetramethyl-;Methylenediamine,N,N',N'-tetramethyl-;N,N',N'-TETRAMETHYLDIAMINOMETHANE;N,N,N,N-Tetramethylmethanediamine;NSC54796;MFCD00008328;bisdimethylaminomethane;Bis-dimethylaminomethane;tetramethyldiaminomethane;bis-dimethylamino-methane;bis (dimethylamino)methane;bis-(dimethylamino)methane;bis-(dimethylamino)-methane;SCHEMBL64976;bis-(di-methylamino)-methane;C(N(C)C)N(C)C;TETRAMETHYLMETHANEDIAMINE;DTXSID1058761;2,4-dimethyl-2,4-diazapentane;dimethylaminomethyl-dimethyl-amine;((CH3)2N)2CH2;N,N,N',N'-tetramethydiaminomethane;n,n,n',n'-tetramethylmethylendiamin;BBL027709;N,N,N',N'-tetramethyidiaminomethane;NSC166169;STL146737;AKOS000121074;N,N,N', N'-tetramethyldiaminomethane;N,N,N',N',-tetramethyldiaminomethane;AT28827;NA 9069;N,N,N',N'-Tetramethyl-methane diamine;N,N,N/',N/'-Tetramethylmethanediamine;LS-90020;VS-08582;N,N,N',N'-Tetramethyldiaminomethane, 99%;FT-0629352;T0969;EN300-23836;N,N,N\',N\'-TETRAMETHYLDIAMINOMETHANE;Q27295126;F0001-1334

Chemical Property of N,N,N',N'-Tetramethylmethanediamine

Chemical Property:

• Appearance/Colour: slightly yellow liquid
• Melting Point: -55°C
• Refractive Index: n20/D 1.401(lit.)
• Boiling Point: 85 °C(lit.)
• PKA: 7.67±0.10(Predicted)
• Flash Point: °C
• PSA: 6.48000
• Density: 0.813g/cm³
• LogP: 0.06710
• Storage Temp.: Flammables area
• Water Solubility.: Fully miscible in water.
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 102.115698455
• Heavy Atom Count: 7
• Complexity: 35.3
• Transport DOT Label: Flammable Liquid

Purity/Quality:

99.9% ^*data from raw suppliers

N,N,N',N'-Tetramethyldiaminomethane >98.0%(GC)(T) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F,C
• Hazard Codes: F,C
• Statements: 11-34
• Safety Statements: 16-26-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Nitrogen Compounds -> Amines, Aliphatic
• Canonical SMILES: CN(C)CN(C)C
• Uses: N,N,N',N'-Tetramethylmethylenediamine is a reagent used as a convenient source of the Mannich intermediate.

Technology Process of N,N,N',N'-Tetramethylmethanediamine

There total 24 articles about N,N,N',N'-Tetramethylmethanediamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + dimethyl amine (124-40-3) → bis-(dimethylamino)methane (51-80-9)

Guidance literature:

In water; at 0 - 20 ℃;

DOI:10.1016/S0040-4020(96)01174-X

Reference yield: 62.0%

(Me2N)2Zr[iPrNC(NMe2)NiPr]2 + oxygen (80937-33-3) → bis-(dimethylamino)methane (51-80-9) + Zr(=O)[iPrNC(NMe2)NiPr]2 + {Zr(μ-O)[iPrNC(NMe2)NiPr]2}2 + {Zr(μ-O)[iPrNC(NMe2)NiPr]2}n + dimethyl amine (124-40-3)

Guidance literature:

In toluene; at 90 ℃; for 40h; under 760.051 Torr; Temperature; Reagent/catalyst; Solvent; Kinetics; Schlenk technique;

DOI:10.1021/ic4016965

Reference yield: 58.4%

Zr(NMe2)2[MeC(NiPr)2]2 + oxygen (80937-33-3) → bis-(dimethylamino)methane (51-80-9) + {(μ-O)Zr[MeC(NiPr)2]2}n + {(μ-O)Zr[MeC(NiPr)2]2}2 + dimethyl amine (124-40-3)

Guidance literature:

In benzene-d6; at 70 ℃; Concentration; Temperature;

DOI:10.1039/c4cc04032e

upstream raw materials:

1,4-dioxane

dimethylchloroamine

diethylmagnesium

dimethyl amine

Downstream raw materials:

methyl-(3-phenyl-propyl)-amine

NCNMe₂

N-bromomethyl-N,N-dimethylamine

dimethylamine hydrobromide

Refernces

• 1、 Hancock,Dickinson. "". . p. 969. Retrieved 1975.
• 2、 Lamb, Adam C.,Wang, Zheng,Cook, Tabitha M.,Sharma, Bhavna,Chen, Shu-Jian,Lu, Zheng,Steren, Carlos A.,Lin, Zhenyang,Xue, Zi-Ling. "Preparation of all N-coordinated zirconium amide amidinates and studies of their reactions with dioxygen and water". . p. 2 - 14. Retrieved 2015/12/09.
• 3、 -. "Method for preparing kakonein derivatives". Paragraph 0025-0026. . Retrieved 2017/03/17.