1(R)-<3-(tert-butyloxycarbonyl)-4(S)-(cyclohexylmethyl)-2,2-dimethyl-5(R)-oxazolidinyl>-2(S)-isopropyl-1,3-propanediol

Base Information

• Chemical Name: 1(R)-<3-(tert-butyloxycarbonyl)-4(S)-(cyclohexylmethyl)-2,2-dimethyl-5(R)-oxazolidinyl>-2(S)-isopropyl-1,3-propanediol
• CAS No.: 134527-83-6
• Molecular Formula: C₂₃H₄₃NO₅
• Molecular Weight: 413.598

Synonyms:1(R)-<3-(tert-butyloxycarbonyl)-4(S)-(cyclohexylmethyl)-2,2-dimethyl-5(R)-oxazolidinyl>-2(S)-isopropyl-1,3-propanediol

Chemical Property of 1(R)-<3-(tert-butyloxycarbonyl)-4(S)-(cyclohexylmethyl)-2,2-dimethyl-5(R)-oxazolidinyl>-2(S)-isopropyl-1,3-propanediol

Chemical Property:

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Technology Process of 1(R)-<3-(tert-butyloxycarbonyl)-4(S)-(cyclohexylmethyl)-2,2-dimethyl-5(R)-oxazolidinyl>-2(S)-isopropyl-1,3-propanediol

There total 3 articles about 1(R)-<3-(tert-butyloxycarbonyl)-4(S)-(cyclohexylmethyl)-2,2-dimethyl-5(R)-oxazolidinyl>-2(S)-isopropyl-1,3-propanediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-<3(R)-<3-(tert-butyloxycarbonyl)-4(S)-cyclohexylmethyl)-2,2-dimethyl-5(R)-oxazolidinyl>-3-hydroxy-2(R)-isopropyl-1-oxopropyl>-4(R)-methyl-5(S)-phenyl-2-oxazolidinone (112190-42-8) → 1(R)-<3-(tert-butyloxycarbonyl)-4(S)-(cyclohexylmethyl)-2,2-dimethyl-5(R)-oxazolidinyl>-2(S)-isopropyl-1,3-propanediol (134527-83-6)

Guidance literature:

Yield given. Multistep reaction;

DOI:10.1021/jm00112a005

Reference yield:

tert-butyl (4S,5R)-4-(cyclohexylmethyl)-5-formyl-2,2-dimethyl-3-oxazolidinecarboxylate (117997-58-7) → 1(R)-<3-(tert-butyloxycarbonyl)-4(S)-(cyclohexylmethyl)-2,2-dimethyl-5(R)-oxazolidinyl>-2(S)-isopropyl-1,3-propanediol (134527-83-6)

Guidance literature:

DOI:10.1021/jm00112a005

Reference yield:

(4R,5S)-(+)-3-[3-methyl-1-oxobut-1-yl]-4-methyl-5-phenyl-2-oxazolidinone (107599-99-5) → 1(R)-<3-(tert-butyloxycarbonyl)-4(S)-(cyclohexylmethyl)-2,2-dimethyl-5(R)-oxazolidinyl>-2(S)-isopropyl-1,3-propanediol (134527-83-6)

Guidance literature:

DOI:10.1021/jm00112a005

upstream raw materials:

3-<3(R)-<3-(tert-butyloxycarbonyl)-4(S)-cyclohexylmethyl)-2,2-dimethyl-5(R)-oxazolidinyl>-3-hydroxy-2(R)-isopropyl-1-oxopropyl>-4(R)-methyl-5(S)-phenyl-2-oxazolidinone

tert-butyl (4S,5R)-4-(cyclohexylmethyl)-5-formyl-2,2-dimethyl-3-oxazolidinecarboxylate

(4R,5S)-(+)-3-[3-methyl-1-oxobut-1-yl]-4-methyl-5-phenyl-2-oxazolidinone

Downstream raw materials:

(2R,3R,4R,5S)-6-Cyclohexyl-3,4-dihydroxy-5-{(S)-3-(1H-imidazol-4-yl)-2-[2-(naphthalen-1-yloxy)-acetylamino]-propionylamino}-2-isopropyl-hexanoic acid {(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butyl}-amide

(2R,3R,4R,5S)-6-Cyclohexyl-3,4-dihydroxy-5-[(S)-3-(1H-imidazol-4-yl)-2-(2-phenoxy-acetylamino)-propionylamino]-2-isopropyl-hexanoic acid {(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butyl}-amide

(2R,3R,4R,5S)-5-[(S)-2-(2-Amino-acetylamino)-3-(1H-imidazol-4-yl)-propionylamino]-6-cyclohexyl-3,4-dihydroxy-2-isopropyl-hexanoic acid {(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butyl}-amide

(2R,3R,4R,5S)-6-Cyclohexyl-3,4-dihydroxy-5-[(S)-2-(2-hydroxy-acetylamino)-3-(1H-imidazol-4-yl)-propionylamino]-2-isopropyl-hexanoic acid {(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butyl}-amide

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