1-(3-(4-(2-(4-methylpyrimidin-2-ylamino)thiazol-4-yl)-1H-pyrazol-3-yl)phenyl)pyrrolidin-3-ol

Base Information

Chemical Name:1-(3-(4-(2-(4-methylpyrimidin-2-ylamino)thiazol-4-yl)-1H-pyrazol-3-yl)phenyl)pyrrolidin-3-ol
CAS No.:1355335-51-1
Molecular Formula:C₂₁H₂₁N₇OS
Molecular Weight:419.51
Hs Code.:

Synonyms:1-(3-(4-(2-(4-methylpyrimidin-2-ylamino)thiazol-4-yl)-1H-pyrazol-3-yl)phenyl)pyrrolidin-3-ol

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Chemical Property of 1-(3-(4-(2-(4-methylpyrimidin-2-ylamino)thiazol-4-yl)-1H-pyrazol-3-yl)phenyl)pyrrolidin-3-ol

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Technology Process of 1-(3-(4-(2-(4-methylpyrimidin-2-ylamino)thiazol-4-yl)-1H-pyrazol-3-yl)phenyl)pyrrolidin-3-ol

There total 5 articles about 1-(3-(4-(2-(4-methylpyrimidin-2-ylamino)thiazol-4-yl)-1H-pyrazol-3-yl)phenyl)pyrrolidin-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1355336-02-5
4-(3-(3-(3-(tert-butyldimethylsilyloxy)pyrrolidin-1-yl)phenyl)-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-N-(4-methylpyrimidin-2-yl)thiazol-2-amine

: 1355335-51-1
1-(3-(4-(2-(4-methylpyrimidin-2-ylamino)thiazol-4-yl)-1H-pyrazol-3-yl)phenyl)pyrrolidin-3-ol

Guidance literature:: With trifluoroacetic acid; at 120 ℃; for 0.166667h; Inert atmosphere; microwave irradiation;

Reference yield:

: 108-36-1
1,3-dibromobenzene

: 1355335-51-1
1-(3-(4-(2-(4-methylpyrimidin-2-ylamino)thiazol-4-yl)-1H-pyrazol-3-yl)phenyl)pyrrolidin-3-ol

Guidance literature:: Multi-step reaction with 5 steps

1: potassium tert-butylate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 3 h / 80 °C / Inert atmosphere

2: 1H-imidazole / acetonitrile / 3 h / 20 °C / Inert atmosphere

3: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 3.5 h / 100 °C / Inert atmosphere

4: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 9 h / 120 °C / Inert atmosphere

5: trifluoroacetic acid / 0.17 h / 120 °C / Inert atmosphere; microwave irradiation

With 1H-imidazole; potassium tert-butylate; potassium acetate; sodium hydrogencarbonate; trifluoroacetic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; water; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 1355335-99-7
1-(3-bromophenyl)pyrrolidin-3-ol

: 1355335-51-1
1-(3-(4-(2-(4-methylpyrimidin-2-ylamino)thiazol-4-yl)-1H-pyrazol-3-yl)phenyl)pyrrolidin-3-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 1H-imidazole / acetonitrile / 3 h / 20 °C / Inert atmosphere

2: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 3.5 h / 100 °C / Inert atmosphere

3: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 9 h / 120 °C / Inert atmosphere

4: trifluoroacetic acid / 0.17 h / 120 °C / Inert atmosphere; microwave irradiation

With 1H-imidazole; potassium acetate; sodium hydrogencarbonate; trifluoroacetic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile;