4-(3-(3-(3-(tert-butyldimethylsilyloxy)pyrrolidin-1-yl)phenyl)-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-N-(4-methylpyrimidin-2-yl)thiazol-2-amine

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Chemical Name:4-(3-(3-(3-(tert-butyldimethylsilyloxy)pyrrolidin-1-yl)phenyl)-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-N-(4-methylpyrimidin-2-yl)thiazol-2-amine
CAS No.:1355336-02-5
Molecular Formula:C₃₅H₄₃N₇O₂SSi
Molecular Weight:653.924
Hs Code.:

Synonyms:4-(3-(3-(3-(tert-butyldimethylsilyloxy)pyrrolidin-1-yl)phenyl)-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-N-(4-methylpyrimidin-2-yl)thiazol-2-amine

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Chemical Property of 4-(3-(3-(3-(tert-butyldimethylsilyloxy)pyrrolidin-1-yl)phenyl)-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-N-(4-methylpyrimidin-2-yl)thiazol-2-amine

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Technology Process of 4-(3-(3-(3-(tert-butyldimethylsilyloxy)pyrrolidin-1-yl)phenyl)-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-N-(4-methylpyrimidin-2-yl)thiazol-2-amine

There total 4 articles about 4-(3-(3-(3-(tert-butyldimethylsilyloxy)pyrrolidin-1-yl)phenyl)-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-N-(4-methylpyrimidin-2-yl)thiazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 1322655-47-9
4-(3-bromo-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-N-(4-methylpyrimidin-2-yl)thiazol-2-amine

: 1355336-01-4
3-(tert-butyldimethylsilyloxy)-1-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyrrolidine

: 1355336-02-5
4-(3-(3-(3-(tert-butyldimethylsilyloxy)pyrrolidin-1-yl)phenyl)-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-N-(4-methylpyrimidin-2-yl)thiazol-2-amine

Guidance literature:: With sodium hydrogencarbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; at 120 ℃; for 9h; Inert atmosphere;

Reference yield:

: 108-36-1
1,3-dibromobenzene

: 1355336-02-5
4-(3-(3-(3-(tert-butyldimethylsilyloxy)pyrrolidin-1-yl)phenyl)-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-N-(4-methylpyrimidin-2-yl)thiazol-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1: potassium tert-butylate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 3 h / 80 °C / Inert atmosphere

2: 1H-imidazole / acetonitrile / 3 h / 20 °C / Inert atmosphere

3: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 3.5 h / 100 °C / Inert atmosphere

4: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 9 h / 120 °C / Inert atmosphere

With 1H-imidazole; potassium tert-butylate; potassium acetate; sodium hydrogencarbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; water; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 1355335-99-7
1-(3-bromophenyl)pyrrolidin-3-ol

: 1355336-02-5
4-(3-(3-(3-(tert-butyldimethylsilyloxy)pyrrolidin-1-yl)phenyl)-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-N-(4-methylpyrimidin-2-yl)thiazol-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1: 1H-imidazole / acetonitrile / 3 h / 20 °C / Inert atmosphere

2: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 3.5 h / 100 °C / Inert atmosphere

3: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 9 h / 120 °C / Inert atmosphere

With 1H-imidazole; potassium acetate; sodium hydrogencarbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile;