2-hydroxymethyl-2',4-dimethoxy-4'-[4-methoxy-3-(methoxymethoxy)phenethyl]biphenyl

Base Information

Chemical Name:2-hydroxymethyl-2',4-dimethoxy-4'-[4-methoxy-3-(methoxymethoxy)phenethyl]biphenyl
CAS No.:1326662-84-3
Molecular Formula:C₂₆H₃₀O₆
Molecular Weight:438.521
Hs Code.:

Synonyms:2-hydroxymethyl-2',4-dimethoxy-4'-[4-methoxy-3-(methoxymethoxy)phenethyl]biphenyl

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Chemical Property of 2-hydroxymethyl-2',4-dimethoxy-4'-[4-methoxy-3-(methoxymethoxy)phenethyl]biphenyl

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Technology Process of 2-hydroxymethyl-2',4-dimethoxy-4'-[4-methoxy-3-(methoxymethoxy)phenethyl]biphenyl

There total 2 articles about 2-hydroxymethyl-2',4-dimethoxy-4'-[4-methoxy-3-(methoxymethoxy)phenethyl]biphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1326662-82-1
methyl 2',4-dimethoxy-4'-[4-methoxy-3-(methoxymethoxy)phenethyl]biphenyl-2-carboxylate

: 1326662-84-3
2-hydroxymethyl-2',4-dimethoxy-4'-[4-methoxy-3-(methoxymethoxy)phenethyl]biphenyl

Guidance literature:: methyl 2',4-dimethoxy-4'-[4-methoxy-3-(methoxymethoxy)phenethyl]biphenyl-2-carboxylate; With diisobutylaluminium hydride; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 2h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; hexane; water; at 0 ℃; Inert atmosphere;
DOI:10.1016/j.tet.2011.06.018

Reference yield:

: methyl 2',4-dimethoxy-4'-[4-methoxy-3-(methoxymethoxy)styryl]biphenyl-2-carboxylate

: 1326662-84-3
2-hydroxymethyl-2',4-dimethoxy-4'-[4-methoxy-3-(methoxymethoxy)phenethyl]biphenyl

Guidance literature:: Multi-step reaction with 2 steps

1.1: 20 % Pd(OH)2/C; hydrogen / N,N-dimethyl-formamide / 20 h / 20 °C

2.1: diisobutylaluminium hydride / tetrahydrofuran; hexane / 2 h / -78 - 20 °C / Inert atmosphere

2.2: 0 °C / Inert atmosphere

With 20 % Pd(OH)2/C; hydrogen; diisobutylaluminium hydride; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2011.06.018

Reference yield: 94.0%

: 1326662-84-3
2-hydroxymethyl-2',4-dimethoxy-4'-[4-methoxy-3-(methoxymethoxy)phenethyl]biphenyl

: 1326662-85-4
2',4-dimethoxy-4'-[4-methoxy-3-(methoxymethoxy)phenethyl]biphenyl-2-carbaldehyde

Guidance literature:: With sulfur trioxide pyridine complex; triethylamine; In dichloromethane; dimethyl sulfoxide; at 0 - 20 ℃; for 2h;
DOI:10.1016/j.tet.2011.06.018