(Z)-2-(4-fluoro-3-nitrostyryl)-2',4-dimethoxy-4'-[4-methoxy-3-(methoxymethoxy)phenethyl]biphenyl

Base Information

Chemical Name:(Z)-2-(4-fluoro-3-nitrostyryl)-2',4-dimethoxy-4'-[4-methoxy-3-(methoxymethoxy)phenethyl]biphenyl
CAS No.:1326662-86-5
Molecular Formula:C₃₃H₃₂FNO₇
Molecular Weight:573.618
Hs Code.:

Synonyms:(Z)-2-(4-fluoro-3-nitrostyryl)-2',4-dimethoxy-4'-[4-methoxy-3-(methoxymethoxy)phenethyl]biphenyl

Suppliers and Price of (Z)-2-(4-fluoro-3-nitrostyryl)-2',4-dimethoxy-4'-[4-methoxy-3-(methoxymethoxy)phenethyl]biphenyl

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (Z)-2-(4-fluoro-3-nitrostyryl)-2',4-dimethoxy-4'-[4-methoxy-3-(methoxymethoxy)phenethyl]biphenyl

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Technology Process of (Z)-2-(4-fluoro-3-nitrostyryl)-2',4-dimethoxy-4'-[4-methoxy-3-(methoxymethoxy)phenethyl]biphenyl

There total 12 articles about (Z)-2-(4-fluoro-3-nitrostyryl)-2',4-dimethoxy-4'-[4-methoxy-3-(methoxymethoxy)phenethyl]biphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 288404-79-5
4-fluoro-3-nitrobenzyltriphenylphosphonium bromide

: 1326662-85-4
2',4-dimethoxy-4'-[4-methoxy-3-(methoxymethoxy)phenethyl]biphenyl-2-carbaldehyde

: 1326662-86-5
(Z)-2-(4-fluoro-3-nitrostyryl)-2',4-dimethoxy-4'-[4-methoxy-3-(methoxymethoxy)phenethyl]biphenyl

Guidance literature:: 4-fluoro-3-nitrobenzyltriphenylphosphonium bromide; With potassium hexamethylsilazane; In tetrahydrofuran; toluene; at 0 - 20 ℃; for 0.5h; Inert atmosphere;

2',4-dimethoxy-4'-[4-methoxy-3-(methoxymethoxy)phenethyl]biphenyl-2-carbaldehyde; In tetrahydrofuran; toluene; at 0 - 20 ℃; for 24h; Inert atmosphere;
DOI:10.1016/j.tet.2011.06.018

Reference yield:

: 1326662-91-2
5-(4-fluoro-3-nitrobenzylsulfonyl)-1-phenyltetrazole

: 1326662-85-4
2',4-dimethoxy-4'-[4-methoxy-3-(methoxymethoxy)phenethyl]biphenyl-2-carbaldehyde

: 1326662-86-5
(Z)-2-(4-fluoro-3-nitrostyryl)-2',4-dimethoxy-4'-[4-methoxy-3-(methoxymethoxy)phenethyl]biphenyl

: 1326662-93-4
(E)-2-(4-fluoro-3-nitrostyryl)-2',4-dimethoxy-4'-[4-methoxy-3-(methoxymethoxy)phenethyl]biphenyl

Guidance literature:: 5-(4-fluoro-3-nitrobenzylsulfonyl)-1-phenyltetrazole; With lithium hexamethyldisilazane; In tetrahydrofuran; toluene; at -78 - 0 ℃; for 0.5h; Inert atmosphere;

2',4-dimethoxy-4'-[4-methoxy-3-(methoxymethoxy)phenethyl]biphenyl-2-carbaldehyde; In tetrahydrofuran; toluene; at -78 - 0 ℃; for 3h; optical yield given as %de; Inert atmosphere;
DOI:10.1016/j.tet.2011.06.018

Reference yield:

: methyl 2',4-dimethoxy-4'-[4-methoxy-3-(methoxymethoxy)styryl]biphenyl-2-carboxylate

: 1326662-86-5
(Z)-2-(4-fluoro-3-nitrostyryl)-2',4-dimethoxy-4'-[4-methoxy-3-(methoxymethoxy)phenethyl]biphenyl

Guidance literature:: Multi-step reaction with 4 steps

1.1: 20 % Pd(OH)2/C; hydrogen / N,N-dimethyl-formamide / 20 h / 20 °C

2.1: diisobutylaluminium hydride / tetrahydrofuran; hexane / 2 h / -78 - 20 °C / Inert atmosphere

2.2: 0 °C / Inert atmosphere

3.1: sulfur trioxide pyridine complex; triethylamine / dichloromethane; dimethyl sulfoxide / 2 h / 0 - 20 °C

4.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.5 h / 0 - 20 °C / Inert atmosphere

4.2: 24 h / 0 - 20 °C / Inert atmosphere

With 20 % Pd(OH)2/C; hydrogen; sulfur trioxide pyridine complex; potassium hexamethylsilazane; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; hexane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; 4.2: Wittig reaction;
DOI:10.1016/j.tet.2011.06.018