2,5-dimethyl-8,9,10,11-tetrahydro[1]benzothieno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine

Base Information

• Chemical Name: 2,5-dimethyl-8,9,10,11-tetrahydro[1]benzothieno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine
• CAS No.: 77995-51-8
• Molecular Formula: C₁₃H₁₄N₄S
• Molecular Weight: 258.347

Synonyms:2,5-dimethyl-8,9,10,11-tetrahydro[1]benzothieno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine

Chemical Property of 2,5-dimethyl-8,9,10,11-tetrahydro[1]benzothieno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine

Chemical Property:

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MSDS Files:

SDS file from LookChem

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Technology Process of 2,5-dimethyl-8,9,10,11-tetrahydro[1]benzothieno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine

There total 4 articles about 2,5-dimethyl-8,9,10,11-tetrahydro[1]benzothieno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

3-amino-4-imino-2-methyl-5,6,7,8-tetrahydrobenzothieno<2,3-d>pyrimidine + Triethyl orthoacetate (78-39-7) → 2,5-dimethyl-8,9,10,11-tetrahydro[1]benzothieno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine (77995-51-8)

Guidance literature:

In N,N-dimethyl-formamide; at 90 ℃; for 4h;

DOI:10.1007/s00044-013-0900-1

Reference yield: 70.0%

4-hydrazinyl-2-methyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine (77995-54-1) + acetic acid (64-19-7,77671-22-8) → 2,5-dimethyl-8,9,10,11-tetrahydro[1]benzothieno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine (77995-51-8)

Guidance literature:

for 5h; Heating;

Reference yield:

3-cyano-2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene (4651-91-6) → 2,5-dimethyl-8,9,10,11-tetrahydro[1]benzothieno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine (77995-51-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 18 h / Reflux

2: hydrazine hydrate / 2 h / 20 °C

3: N,N-dimethyl-formamide / 4 h / 90 °C

With hydrazine hydrate; In N,N-dimethyl-formamide;

DOI:10.1007/s00044-013-0900-1

upstream raw materials:

4-hydrazinyl-2-methyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine

acetic acid

Triethyl orthoacetate

3-cyano-2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene

Downstream raw materials:

2-Methyl-4-((E)-styryl)-7,8,9,10-tetrahydro-6-thia-1,3,3a,5-tetraaza-cyclopenta[c]fluorene

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