2-Methyl-4-((E)-styryl)-7,8,9,10-tetrahydro-6-thia-1,3,3a,5-tetraaza-cyclopenta[c]fluorene

Base Information

• Chemical Name: 2-Methyl-4-((E)-styryl)-7,8,9,10-tetrahydro-6-thia-1,3,3a,5-tetraaza-cyclopenta[c]fluorene
• CAS No.: 101130-24-9
• Molecular Formula: C₂₀H₁₈N₄S
• Molecular Weight: 346.456

Synonyms:2-Methyl-4-((E)-styryl)-7,8,9,10-tetrahydro-6-thia-1,3,3a,5-tetraaza-cyclopenta[c]fluorene

Chemical Property of 2-Methyl-4-((E)-styryl)-7,8,9,10-tetrahydro-6-thia-1,3,3a,5-tetraaza-cyclopenta[c]fluorene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Methyl-4-((E)-styryl)-7,8,9,10-tetrahydro-6-thia-1,3,3a,5-tetraaza-cyclopenta[c]fluorene

There total 12 articles about 2-Methyl-4-((E)-styryl)-7,8,9,10-tetrahydro-6-thia-1,3,3a,5-tetraaza-cyclopenta[c]fluorene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2,5-dimethyl-8,9,10,11-tetrahydro[1]benzothieno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine (77995-51-8) + benzaldehyde (100-52-7) → 2-Methyl-4-((E)-styryl)-7,8,9,10-tetrahydro-6-thia-1,3,3a,5-tetraaza-cyclopenta[c]fluorene (101130-24-9)

Guidance literature:

With sodium ethanolate; In ethanol; 1.)50-60 deg C, 15-20 min 2.)r.t., 12 h;

DOI:10.1002/jhet.5570220343

Reference yield:

ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (4506-71-2) → 2-Methyl-4-((E)-styryl)-7,8,9,10-tetrahydro-6-thia-1,3,3a,5-tetraaza-cyclopenta[c]fluorene (101130-24-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 58 percent / HCl(g) / dioxane / Ambient temperature

2: 77 percent / POCl₃/DMF / 1.)0-5 deg C, 15-20 min 2.)r.t., 12 h

3: 62 percent / 99percent N₂H₄*H₂O / ethanol / 2 h / Heating

4: 81 percent / 3.5 h / Heating

5: NaOEt / ethanol / 1.)heating, 15-30 min 2.)r.t., 12 h

With hydrogenchloride; sodium ethanolate; hydrazine hydrate; N,N-dimethyl-formamide; trichlorophosphate; In 1,4-dioxane; ethanol;

DOI:10.1002/jhet.5570220343

Reference yield:

cinnamonitrile (4360-47-8) → 2-Methyl-4-((E)-styryl)-7,8,9,10-tetrahydro-6-thia-1,3,3a,5-tetraaza-cyclopenta[c]fluorene (101130-24-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 58 percent / HCl(g) / dioxane / Ambient temperature

2: 77 percent / POCl₃/DMF / 1.)0-5 deg C, 15-20 min 2.)r.t., 12 h

3: 62 percent / 99percent N₂H₄*H₂O / ethanol / 2 h / Heating

4: 81 percent / 3.5 h / Heating

5: NaOEt / ethanol / 1.)heating, 15-30 min 2.)r.t., 12 h

With hydrogenchloride; sodium ethanolate; hydrazine hydrate; N,N-dimethyl-formamide; trichlorophosphate; In 1,4-dioxane; ethanol;

DOI:10.1002/jhet.5570220343

upstream raw materials:

3-Methyl-4-((E)-styryl)-7,8,9,10-tetrahydro-6-thia-1,2,3a,5-tetraaza-cyclopenta[c]fluorene

2,5-dimethyl-8,9,10,11-tetrahydro[1]benzothieno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine

benzaldehyde

cinnamonitrile

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