(1S,8aS)-N-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethyl)-7,7-bis(hydroxymethyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide

Base Information

Chemical Name:(1S,8aS)-N-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethyl)-7,7-bis(hydroxymethyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide
CAS No.:1453069-18-5
Molecular Formula:C₂₈H₃₁F₆N₃O₄
Molecular Weight:587.562
Hs Code.:

(1S,8aS)-N-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethyl)-7,7-bis(hydroxymethyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide

Synonyms:(1S,8aS)-N-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethyl)-7,7-bis(hydroxymethyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide

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Chemical Property of (1S,8aS)-N-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethyl)-7,7-bis(hydroxymethyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide

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Technology Process of (1S,8aS)-N-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethyl)-7,7-bis(hydroxymethyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide

There total 9 articles about (1S,8aS)-N-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethyl)-7,7-bis(hydroxymethyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 3.9%

: 1453070-40-0
(1S,8aS)-dimethyl 2-(methyl((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethyl)carbamoyl)-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-7,7(6H)-dicarboxylate

: 1453069-18-5
(1S,8aS)-N-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethyl)-7,7-bis(hydroxymethyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide

Guidance literature:: With methanol; lithium borohydride; at 0 - 20 ℃; for 2h;

Reference yield:

: 1453068-21-7
(1S,8aS)-N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-N-methyl-1-(2-methylphenyl)-6-oxo-octahydropyrrolo[1,2-a]piperazine-2-carboxamide

: 1453069-18-5
(1S,8aS)-N-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethyl)-7,7-bis(hydroxymethyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -60 °C / Inert atmosphere

1.2: 3 h / -60 - 20 °C

2.1: lithium borohydride; methanol / 2 h / 0 - 20 °C

With methanol; lithium borohydride; lithium hexamethyldisilazane; In tetrahydrofuran;

Reference yield:

: 1228573-50-9
N-[2-(benzyloxycarbonylamino)ethyl]pent-4-ynamide

: 1453069-18-5
(1S,8aS)-N-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethyl)-7,7-bis(hydroxymethyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide / 3 h / 25 °C / Inert atmosphere

2.1: bis-[(trifluoroacetoxy)iodo]benzene / 2,2,2-trifluoroethanol / 3 h / 0 °C

3.1: hydrogenchloride; 5%-palladium/activated carbon; hydrogen / methanol; water / 30 h / 3800.26 Torr

4.1: triethylamine / ethyl acetate / 2 h / 0 °C

4.2: 39 h

5.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -60 °C / Inert atmosphere

5.2: 3 h / -60 - 20 °C

6.1: lithium borohydride; methanol / 2 h / 0 - 20 °C

With hydrogenchloride; methanol; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; lithium borohydride; 5%-palladium/activated carbon; hydrogen; triethylamine; bis-[(trifluoroacetoxy)iodo]benzene; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; 2,2,2-trifluoroethanol; water; ethyl acetate; N,N-dimethyl-formamide;