(1S,8aS)-dimethyl 2-(methyl((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethyl)carbamoyl)-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-7,7(6H)-dicarboxylate

Base Information

Chemical Name:(1S,8aS)-dimethyl 2-(methyl((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethyl)carbamoyl)-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-7,7(6H)-dicarboxylate
CAS No.:1453070-40-0
Molecular Formula:C₃₀H₃₁F₆N₃O₆
Molecular Weight:643.583
Hs Code.:

(1S,8aS)-dimethyl 2-(methyl((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethyl)carbamoyl)-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-7,7(6H)-dicarboxylate

Synonyms:(1S,8aS)-dimethyl 2-(methyl((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethyl)carbamoyl)-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-7,7(6H)-dicarboxylate

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Chemical Property of (1S,8aS)-dimethyl 2-(methyl((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethyl)carbamoyl)-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-7,7(6H)-dicarboxylate

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Technology Process of (1S,8aS)-dimethyl 2-(methyl((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethyl)carbamoyl)-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-7,7(6H)-dicarboxylate

There total 8 articles about (1S,8aS)-dimethyl 2-(methyl((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethyl)carbamoyl)-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-7,7(6H)-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.3%

: 1453068-21-7
(1S,8aS)-N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-N-methyl-1-(2-methylphenyl)-6-oxo-octahydropyrrolo[1,2-a]piperazine-2-carboxamide

: 79-22-1
methyl chloroformate

: 1453070-40-0
(1S,8aS)-dimethyl 2-(methyl((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethyl)carbamoyl)-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-7,7(6H)-dicarboxylate

Guidance literature:: (1S,8aS)-N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-N-methyl-1-(2-methylphenyl)-6-oxo-octahydropyrrolo[1,2-a]piperazine-2-carboxamide; With lithium hexamethyldisilazane; In tetrahydrofuran; at -60 ℃; for 0.5h; Inert atmosphere;

methyl chloroformate; In tetrahydrofuran; at -60 - 20 ℃; for 3h;

Reference yield:

: 1228573-50-9
N-[2-(benzyloxycarbonylamino)ethyl]pent-4-ynamide

: 1453070-40-0
(1S,8aS)-dimethyl 2-(methyl((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethyl)carbamoyl)-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-7,7(6H)-dicarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide / 3 h / 25 °C / Inert atmosphere

2.1: bis-[(trifluoroacetoxy)iodo]benzene / 2,2,2-trifluoroethanol / 3 h / 0 °C

3.1: hydrogenchloride; 5%-palladium/activated carbon; hydrogen / methanol; water / 30 h / 3800.26 Torr

4.1: triethylamine / ethyl acetate / 2 h / 0 °C

4.2: 39 h

5.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -60 °C / Inert atmosphere

5.2: 3 h / -60 - 20 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; 5%-palladium/activated carbon; hydrogen; triethylamine; bis-[(trifluoroacetoxy)iodo]benzene; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; 2,2,2-trifluoroethanol; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1453069-32-3
benzyl N-{2-[5-(2-methylphenyl)pent-4-ynamido]ethyl}carbamate

: 1453070-40-0
(1S,8aS)-dimethyl 2-(methyl((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethyl)carbamoyl)-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-7,7(6H)-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: bis-[(trifluoroacetoxy)iodo]benzene / 2,2,2-trifluoroethanol / 3 h / 0 °C

2.1: hydrogenchloride; 5%-palladium/activated carbon; hydrogen / methanol; water / 30 h / 3800.26 Torr

3.1: triethylamine / ethyl acetate / 2 h / 0 °C

3.2: 39 h

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -60 °C / Inert atmosphere

4.2: 3 h / -60 - 20 °C

With hydrogenchloride; 5%-palladium/activated carbon; hydrogen; triethylamine; bis-[(trifluoroacetoxy)iodo]benzene; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; 2,2,2-trifluoroethanol; water; ethyl acetate;