8-fluoro-5-(phenylsulfonyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-1-one

Base Information

Chemical Name:8-fluoro-5-(phenylsulfonyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-1-one
CAS No.:1365762-34-0
Molecular Formula:C₁₇H₁₃FN₂O₃S
Molecular Weight:344.366
Hs Code.:

Synonyms:8-fluoro-5-(phenylsulfonyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-1-one

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Chemical Property of 8-fluoro-5-(phenylsulfonyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-1-one

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Technology Process of 8-fluoro-5-(phenylsulfonyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-1-one

There total 3 articles about 8-fluoro-5-(phenylsulfonyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.6%

: 128487-04-7
8-fluoro-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-1-one

: 98-09-9
benzenesulfonyl chloride

: 1365762-34-0
8-fluoro-5-(phenylsulfonyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-1-one

Guidance literature:: 8-fluoro-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-1-one; With sodium hydride; In N,N-dimethyl-formamide; at -10 - 20 ℃; for 0.166667h;

benzenesulfonyl chloride; at 0 - 20 ℃;

With water; Cooling with ice;

Reference yield:

: 371-40-4
4-fluoroaniline

: 1365762-34-0
8-fluoro-5-(phenylsulfonyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-1-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: 5 h / 120 °C / Inert atmosphere

2.1: copper diacetate / palladium diacetate / N,N-dimethyl-formamide / 2 h / 130 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / -10 - 20 °C

3.2: 0 - 20 °C

3.3: Cooling with ice

With copper diacetate; sodium hydride; palladium diacetate; In N,N-dimethyl-formamide;

Reference yield:

: 128486-98-6
4-(4-fluorophenylamino)-5,6-dihydropyridin-2(1H)-one

: 1365762-34-0
8-fluoro-5-(phenylsulfonyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-1-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: copper diacetate / palladium diacetate / N,N-dimethyl-formamide / 2 h / 130 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / -10 - 20 °C

2.2: 0 - 20 °C

2.3: Cooling with ice

With copper diacetate; sodium hydride; palladium diacetate; In N,N-dimethyl-formamide;