1-(3-isopropyl-4-triisopropylsilanyloxybenzyl)-2-methyl-1H-indol-4-ylamine

Base Information

Chemical Name:1-(3-isopropyl-4-triisopropylsilanyloxybenzyl)-2-methyl-1H-indol-4-ylamine
CAS No.:1000605-24-2
Molecular Formula:C₂₈H₄₂N₂OSi
Molecular Weight:450.74
Hs Code.:

Synonyms:1-(3-isopropyl-4-triisopropylsilanyloxybenzyl)-2-methyl-1H-indol-4-ylamine

Suppliers and Price of 1-(3-isopropyl-4-triisopropylsilanyloxybenzyl)-2-methyl-1H-indol-4-ylamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 1-(3-isopropyl-4-triisopropylsilanyloxybenzyl)-2-methyl-1H-indol-4-ylamine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-(3-isopropyl-4-triisopropylsilanyloxybenzyl)-2-methyl-1H-indol-4-ylamine

There total 6 articles about 1-(3-isopropyl-4-triisopropylsilanyloxybenzyl)-2-methyl-1H-indol-4-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1000604-27-2
1-(3-isopropyl-4-triisopropylsilanyloxybenzyl)-2-methyl-4-nitro-1H-indole

: 1000605-24-2
1-(3-isopropyl-4-triisopropylsilanyloxybenzyl)-2-methyl-1H-indol-4-ylamine

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; ethanol; at 20 ℃; for 3h;
DOI:10.1016/j.bmc.2013.11.001

Reference yield:

: 26307-50-6
4-bromo-2-isopropyl-phenol

: 1000605-24-2
1-(3-isopropyl-4-triisopropylsilanyloxybenzyl)-2-methyl-1H-indol-4-ylamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 24 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran; pentane / 2 h / -78 °C

2.2: 4 h / -78 - 20 °C

3.1: thionyl chloride / dichloromethane / 2 h / 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 5 °C

4.2: 3 h / 5 °C

5.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 3 h / 20 °C

With 1H-imidazole; n-butyllithium; thionyl chloride; palladium 10% on activated carbon; hydrogen; sodium hydride; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; mineral oil; pentane;
DOI:10.1016/j.bmc.2013.11.001

Reference yield:

: 88-69-7
2-(1-methylethyl)phenol

: 1000605-24-2
1-(3-isopropyl-4-triisopropylsilanyloxybenzyl)-2-methyl-1H-indol-4-ylamine

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-Bromosuccinimide / acetonitrile / 4 h / 0 - 20 °C

2.1: 1H-imidazole / N,N-dimethyl-formamide / 24 h / 20 °C

3.1: n-butyllithium / tetrahydrofuran; pentane / 2 h / -78 °C

3.2: 4 h / -78 - 20 °C

4.1: thionyl chloride / dichloromethane / 2 h / 20 °C

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 5 °C

5.2: 3 h / 5 °C

6.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 3 h / 20 °C

With 1H-imidazole; N-Bromosuccinimide; n-butyllithium; thionyl chloride; palladium 10% on activated carbon; hydrogen; sodium hydride; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; mineral oil; pentane;
DOI:10.1016/j.bmc.2013.11.001