1-(3-isopropyl-4-triisopropylsilanyloxybenzyl)-2-methyl-4-nitro-1H-indole

Base Information

Chemical Name:1-(3-isopropyl-4-triisopropylsilanyloxybenzyl)-2-methyl-4-nitro-1H-indole
CAS No.:1000604-27-2
Molecular Formula:C₂₈H₄₀N₂O₃Si
Molecular Weight:480.723
Hs Code.:

Synonyms:1-(3-isopropyl-4-triisopropylsilanyloxybenzyl)-2-methyl-4-nitro-1H-indole

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Chemical Property of 1-(3-isopropyl-4-triisopropylsilanyloxybenzyl)-2-methyl-4-nitro-1H-indole

Chemical Property:

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Technology Process of 1-(3-isopropyl-4-triisopropylsilanyloxybenzyl)-2-methyl-4-nitro-1H-indole

There total 5 articles about 1-(3-isopropyl-4-triisopropylsilanyloxybenzyl)-2-methyl-4-nitro-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3484-10-4
2-methyl-4-nitro-1H-indole

: 1000604-24-9
(4-chloromethyl-2-isopropylphenoxy)triisopropylsilane

: 1000604-27-2
1-(3-isopropyl-4-triisopropylsilanyloxybenzyl)-2-methyl-4-nitro-1H-indole

Guidance literature:: 2-methyl-4-nitro-1H-indole; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 5 ℃; for 1h;

(4-chloromethyl-2-isopropylphenoxy)triisopropylsilane; In N,N-dimethyl-formamide; mineral oil; at 5 ℃; for 3h;
DOI:10.1016/j.bmc.2013.11.001

Reference yield:

: 26307-50-6
4-bromo-2-isopropyl-phenol

: 1000604-27-2
1-(3-isopropyl-4-triisopropylsilanyloxybenzyl)-2-methyl-4-nitro-1H-indole

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 24 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran; pentane / 2 h / -78 °C

2.2: 4 h / -78 - 20 °C

3.1: thionyl chloride / dichloromethane / 2 h / 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 5 °C

4.2: 3 h / 5 °C

With 1H-imidazole; n-butyllithium; thionyl chloride; sodium hydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil; pentane;
DOI:10.1016/j.bmc.2013.11.001

Reference yield:

: 88-69-7
2-(1-methylethyl)phenol

: 1000604-27-2
1-(3-isopropyl-4-triisopropylsilanyloxybenzyl)-2-methyl-4-nitro-1H-indole

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-Bromosuccinimide / acetonitrile / 4 h / 0 - 20 °C

2.1: 1H-imidazole / N,N-dimethyl-formamide / 24 h / 20 °C

3.1: n-butyllithium / tetrahydrofuran; pentane / 2 h / -78 °C

3.2: 4 h / -78 - 20 °C

4.1: thionyl chloride / dichloromethane / 2 h / 20 °C

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 5 °C

5.2: 3 h / 5 °C

With 1H-imidazole; N-Bromosuccinimide; n-butyllithium; thionyl chloride; sodium hydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile; mineral oil; pentane;
DOI:10.1016/j.bmc.2013.11.001