Isobutyric acid (1R,8S,9S)-10,10-dimethyl-5-phenyl-6-aza-tricyclo[7.1.1.0^2,7]undeca-2⁽⁷⁾,3,5-trien-8-yl ester

Base Information

• Chemical Name: Isobutyric acid (1R,8S,9S)-10,10-dimethyl-5-phenyl-6-aza-tricyclo[7.1.1.0^2,7]undeca-2⁽⁷⁾,3,5-trien-8-yl ester
• CAS No.: 173787-60-5
• Molecular Formula: C₂₂H₂₅NO₂
• Molecular Weight: 335.446
• Mol file: 173787-60-5.mol

Synonyms:Isobutyric acid (1R,8S,9S)-10,10-dimethyl-5-phenyl-6-aza-tricyclo[7.1.1.0^2,7]undeca-2⁽⁷⁾,3,5-trien-8-yl ester

Chemical Property of Isobutyric acid (1R,8S,9S)-10,10-dimethyl-5-phenyl-6-aza-tricyclo[7.1.1.0^2,7]undeca-2⁽⁷⁾,3,5-trien-8-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Isobutyric acid (1R,8S,9S)-10,10-dimethyl-5-phenyl-6-aza-tricyclo[7.1.1.0^2,7]undeca-2⁽⁷⁾,3,5-trien-8-yl ester

There total 2 articles about Isobutyric acid (1R,8S,9S)-10,10-dimethyl-5-phenyl-6-aza-tricyclo[7.1.1.0^2,7]undeca-2⁽⁷⁾,3,5-trien-8-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(-)-(1R,5R)-2,3-(2'-Phenyl-1'-azobenzo)-6,6-dimethylbicyclo[3.1.1]heptane (173787-59-2) → Isobutyric acid (1R,8S,9S)-10,10-dimethyl-5-phenyl-6-aza-tricyclo[7.1.1.02,7]undeca-2(7),3,5-trien-8-yl ester (173787-60-5)

Guidance literature:

Multi-step reaction with 2 steps

1: HOOAc / acetic acid / 24 h / 70 °C

2: 8 h / 100 °C

With peracetic acid; In acetic acid;

DOI:10.1016/0957-4166(95)00381-9

Reference yield:

2-Methylpropionic anhydride (97-72-3) + (1R,9R)-10,10-Dimethyl-5-phenyl-6-aza-tricyclo[7.1.1.02,7]undeca-2(7),3,5-triene 6-oxide → Isobutyric acid (1R,8S,9S)-10,10-dimethyl-5-phenyl-6-aza-tricyclo[7.1.1.02,7]undeca-2(7),3,5-trien-8-yl ester (173787-60-5) + Isobutyric acid (1R,8R,9S)-10,10-dimethyl-5-phenyl-6-aza-tricyclo[7.1.1.02,7]undeca-2(7),3,5-trien-8-yl ester (173936-40-8)

Guidance literature:

at 100 ℃; for 8h; Yield given. Yields of byproduct given;

DOI:10.1016/0957-4166(95)00381-9

Reference yield: 95.0%

Isobutyric acid (1R,8S,9S)-10,10-dimethyl-5-phenyl-6-aza-tricyclo[7.1.1.02,7]undeca-2(7),3,5-trien-8-yl ester (173787-60-5) → (5R,7S,8S)-8-hydroxy-5,6,7,8-Tetrahydro-6,6-dimethyl-2-phenyl-5,7-methanoquinoline (173787-61-6)

Guidance literature:

With sodium hydroxide; In methanol; for 1h; Heating;

DOI:10.1016/0957-4166(95)00381-9

upstream raw materials:

2-Methylpropionic anhydride

(-)-(1R,5R)-2,3-(2'-Phenyl-1'-azobenzo)-6,6-dimethylbicyclo[3.1.1]heptane

Downstream raw materials:

(5R,7S,8S)-8-hydroxy-5,6,7,8-Tetrahydro-6,6-dimethyl-2-phenyl-5,7-methanoquinoline