2-[2-(4-tert-butylphenyl)ethyl]-N-[4-(2-cyclohexylethoxy)-2-fluorophenyl]-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide

Base Information

Chemical Name:2-[2-(4-tert-butylphenyl)ethyl]-N-[4-(2-cyclohexylethoxy)-2-fluorophenyl]-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide
CAS No.:1400648-23-8
Molecular Formula:C₃₅H₄₅FN₂O₃S
Molecular Weight:592.818
Hs Code.:

Synonyms:2-[2-(4-tert-butylphenyl)ethyl]-N-[4-(2-cyclohexylethoxy)-2-fluorophenyl]-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide

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Chemical Property of 2-[2-(4-tert-butylphenyl)ethyl]-N-[4-(2-cyclohexylethoxy)-2-fluorophenyl]-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide

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Technology Process of 2-[2-(4-tert-butylphenyl)ethyl]-N-[4-(2-cyclohexylethoxy)-2-fluorophenyl]-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide

There total 4 articles about 2-[2-(4-tert-butylphenyl)ethyl]-N-[4-(2-cyclohexylethoxy)-2-fluorophenyl]-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1400648-21-6
2-[(4-tert-butylphenyl)acetyl]-N-[4-(2-cyclohexylethoxy)-2-fluorophenyl]-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide

: 1400648-23-8
2-[2-(4-tert-butylphenyl)ethyl]-N-[4-(2-cyclohexylethoxy)-2-fluorophenyl]-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide

Guidance literature:: With borane-THF; In tetrahydrofuran; at 95 ℃; for 6h;

Reference yield:

: 1400648-22-7
2-[(4-tert-butylphenyl)acetyl]-N-[4-(2-cyclohexylethoxy)-2-fluorophenyl]-N-(2,4-dimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide

: 1400648-23-8
2-[2-(4-tert-butylphenyl)ethyl]-N-[4-(2-cyclohexylethoxy)-2-fluorophenyl]-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / chloroform / 1 h / 20 °C

2: borane-THF / tetrahydrofuran / 6 h / 95 °C

With borane-THF; trifluoroacetic acid; In tetrahydrofuran; chloroform;

Reference yield:

: 3549-23-3
methyl 2-(4-tert-butylphenyl)acetate

: 1400648-23-8
2-[2-(4-tert-butylphenyl)ethyl]-N-[4-(2-cyclohexylethoxy)-2-fluorophenyl]-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / methanol; water; tetrahydrofuran / 3 h / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 19 h / 20 °C

3: trifluoroacetic acid / chloroform / 1 h / 20 °C

4: borane-THF / tetrahydrofuran / 6 h / 95 °C

With borane-THF; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; chloroform; water; N,N-dimethyl-formamide;