2-[(4-tert-butylphenyl)acetyl]-N-[4-(2-cyclohexylethoxy)-2-fluorophenyl]-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide

Base Information

Chemical Name:2-[(4-tert-butylphenyl)acetyl]-N-[4-(2-cyclohexylethoxy)-2-fluorophenyl]-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide
CAS No.:1400648-21-6
Molecular Formula:C₃₅H₄₃FN₂O₄S
Molecular Weight:606.802
Hs Code.:

Synonyms:2-[(4-tert-butylphenyl)acetyl]-N-[4-(2-cyclohexylethoxy)-2-fluorophenyl]-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide

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Chemical Property of 2-[(4-tert-butylphenyl)acetyl]-N-[4-(2-cyclohexylethoxy)-2-fluorophenyl]-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide

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Technology Process of 2-[(4-tert-butylphenyl)acetyl]-N-[4-(2-cyclohexylethoxy)-2-fluorophenyl]-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide

There total 14 articles about 2-[(4-tert-butylphenyl)acetyl]-N-[4-(2-cyclohexylethoxy)-2-fluorophenyl]-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1400648-22-7
2-[(4-tert-butylphenyl)acetyl]-N-[4-(2-cyclohexylethoxy)-2-fluorophenyl]-N-(2,4-dimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide

: 1400648-21-6
2-[(4-tert-butylphenyl)acetyl]-N-[4-(2-cyclohexylethoxy)-2-fluorophenyl]-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide

Guidance literature:: With trifluoroacetic acid; In chloroform; at 20 ℃; for 1h;

Reference yield:

: 32857-63-9
4-t-butylphenylacetic acid

: 1400648-21-6
2-[(4-tert-butylphenyl)acetyl]-N-[4-(2-cyclohexylethoxy)-2-fluorophenyl]-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 19 h / 20 °C

2: trifluoroacetic acid / chloroform / 1 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In chloroform; N,N-dimethyl-formamide;

Reference yield:

: 3549-23-3
methyl 2-(4-tert-butylphenyl)acetate

: 1400648-21-6
2-[(4-tert-butylphenyl)acetyl]-N-[4-(2-cyclohexylethoxy)-2-fluorophenyl]-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / methanol; water; tetrahydrofuran / 3 h / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 19 h / 20 °C

3: trifluoroacetic acid / chloroform / 1 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; chloroform; water; N,N-dimethyl-formamide;