Hydroxy-PEG2-CH2CO2t-Bu

Base Information

• Chemical Name: Hydroxy-PEG2-CH2CO2t-Bu
• CAS No.: 149299-82-1
• Molecular Formula: C₁₀H₂₀O₅
• Molecular Weight: 220.266
• Hs Code.: 2942000090
• Mol file: 149299-82-1.mol

Synonyms:tert-butyl 2-(2-(2-hydroxyethoxy)ethoxy)acetate

Chemical Property of Hydroxy-PEG2-CH2CO2t-Bu

Chemical Property:

• Boiling Point: 306.1±22.0 °C(Predicted)
• PKA: 14.35±0.10(Predicted)
• Density: 1.062±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• Solubility.: Soluble in Water, DMSO, DCM, DMF

Purity/Quality:

98%,99%, ^*data from raw suppliers

Hydroxy-PEG2-CH2CO2tBu ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Hydroxy-PEG2-CH2CO2tBu is a PEG linker containing a hydroxyl group with a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
• Uses: Hydroxy-PEG2-CH2CO2tBu was a useful reagent in the study for potentiator-corrector agonist of cystic fibrosis mutant protein ΔF508-CFTR preparation.

Technology Process of Hydroxy-PEG2-CH2CO2t-Bu

There total 5 articles about Hydroxy-PEG2-CH2CO2t-Bu which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

tert-butyl 2-(2-(2-(benzyloxy)ethoxy)ethoxy)acetate → tert-butyl 2-(2-(2-hydroxyethoxy)ethoxy)acetate (149299-82-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 18h; under 2585.81 Torr;

Reference yield: 56.0%

bromoacetic acid tert-butyl ester (5292-43-3) + diethylene glycol (111-46-6) → tert-butyl 2-(2-(2-hydroxyethoxy)ethoxy)acetate (149299-82-1)

Guidance literature:

diethylene glycol; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 2h; Inert atmosphere;

bromoacetic acid tert-butyl ester; In tetrahydrofuran; at 0 ℃; for 12h; Inert atmosphere;

Reference yield:

sodium dihydrogenphosphate (10049-21-5) + bromoacetic acid tert-butyl ester (5292-43-3) + diethylene glycol (111-46-6) → tert-butyl 2-(2-(2-hydroxyethoxy)ethoxy)acetate (149299-82-1)

Guidance literature:

With sodium hexamethyldisilazane; In tetrahydrofuran;

upstream raw materials:

bromoacetic acid tert-butyl ester

diethylene glycol

sodium dihydrogenphosphate

Downstream raw materials:

tert-butyl 2-[2-[2-(p-tolylsulfonyloxy)ethoxy]ethoxy]acetate

Refernces

• 1、 -. "Compound targeting ubiquitination degradation tyrosinase as well as preparation method and application thereof". Paragraph 0064-0065. . Retrieved 2021/09/08.
• 2、 Tu, Yalin,Sun, Yameng,Qiao, Shuang,Luo, Yao,Liu, Panpan,Jiang, Zhong-Xing,Hu, Yumin,Wang, Zifeng,Huang, Peng,Wen, Shijun. "Design, Synthesis, and Evaluation of VHL-Based EZH2 Degraders to Enhance Therapeutic Activity against Lymphoma". . p. 10167 - 10184. Retrieved 2021/07/26.