[2-(2-Hydroxyethoxy)ethoxy]acetic acid tert-butyl ester

Base Information

Chemical Name:[2-(2-Hydroxyethoxy)ethoxy]acetic acid tert-butyl ester
CAS No.:149299-82-1
Molecular Formula:C₁₀H₂₀O₅
Molecular Weight:220.266
Hs Code.:2942000090
European Community (EC) Number:882-076-2
Mol file:149299-82-1.mol

Synonyms:149299-82-1;Hydroxy-PEG2-CH2CO2tBu;tert-Butyl 2-(2-(2-hydroxyethoxy)ethoxy)acetate;Hydroxy-PEG2-t-butyl acetate;HO-PEG2-CH2COOtBu;Hydroxy-PEG2-CH2-Boc;tert-butyl 2-[2-(2-hydroxyethoxy)ethoxy]acetate;[2-(2-hydroxyethoxy)ethoxy]acetic acid tert-butyl ester;Acetic acid, [2-(2-hydroxyethoxy)ethoxy]-, 1,1-dimethylethyl ester;Hydroxy-PEG2-CH2CO2t-Bu;MFCD25959245;C10H20O5;OH-PEG2-CH2COOtBu;Hydroxy-PEG2-CH2COOtBu;SCHEMBL1401413;LMDJRQVQNFNFAK-UHFFFAOYSA-N;ZFA29982;AKOS028109937;HO-PEG-CH2CO2tBu, MW 1,000;HO-PEG-CH2CO2tBu, MW 2,000;HO-PEG-CH2CO2tBu, MW 3,400;HO-PEG-CH2CO2tBu, MW 5,000;HO-PEG-CH2CO2tBu, MW 10,000;AS-54487;BP-22082;BP-25920;BP-25921;BP-25922;BP-25923;BP-25924;SY245061;DB-144908;HY-130599;tert-butyl 8-hydroxy -3,6- dioxaoctanoate;CS-0109371;S10549;tert-Butyl2-(2-(2-hydroxyethoxy)ethoxy)acetate;A900808

Suppliers and Price of [2-(2-Hydroxyethoxy)ethoxy]acetic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Hydroxy-PEG2-CH2CO2tBu
250mg
$ 460.00

TRC
Hydroxy-PEG2-CH2CO2tBu
0.5g
$ 275.00

purepeg
HO-PEG2-CH2COOtBu min.97%
1 g
$ 120.00

BroadPharm
Hydroxy-PEG2-CH2CO2tBu 95%
500 MG
$ 430.00

BroadPharm
Hydroxy-PEG2-CH2CO2tBu 95%
1 G
$ 680.00

BroadPharm
Hydroxy-PEG2-CH2CO2tBu 95%
5 G
$ 1850.00

Ambeed
tert-Butyl2-(2-(2-hydroxyethoxy)ethoxy)acetate 95%
5g
$ 625.00

Ambeed
tert-Butyl2-(2-(2-hydroxyethoxy)ethoxy)acetate 95%
1g
$ 174.00

Ambeed
tert-Butyl2-(2-(2-hydroxyethoxy)ethoxy)acetate 95%
250mg
$ 72.00

Ambeed
tert-Butyl2-(2-(2-hydroxyethoxy)ethoxy)acetate 95%
100mg
$ 37.00

Total 15 raw suppliers

Chemical Property of [2-(2-Hydroxyethoxy)ethoxy]acetic acid tert-butyl ester

Chemical Property:

Boiling Point:306.1±22.0 °C(Predicted)
PKA:14.35±0.10(Predicted)
Density:1.062±0.06 g/cm3(Predicted)
Storage Temp.:2-8°C
Solubility.:Soluble in Water, DMSO, DCM, DMF
XLogP3:0.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:9
Exact Mass:220.13107373
Heavy Atom Count:15
Complexity:173

Purity/Quality:

97% ^*data from raw suppliers

Hydroxy-PEG2-CH2CO2tBu ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)COCCOCCO
Description Hydroxy-PEG2-CH2CO2tBu is a PEG linker containing a hydroxyl group with a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
Uses Hydroxy-PEG2-CH2CO2tBu was a useful reagent in the study for potentiator-corrector agonist of cystic fibrosis mutant protein ΔF508-CFTR preparation.

Technology Process of [2-(2-Hydroxyethoxy)ethoxy]acetic acid tert-butyl ester

There total 5 articles about [2-(2-Hydroxyethoxy)ethoxy]acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: tert-butyl 2-(2-(2-(benzyloxy)ethoxy)ethoxy)acetate

: 149299-82-1
tert-butyl 2-(2-(2-hydroxyethoxy)ethoxy)acetate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 18h; under 2585.81 Torr;

Reference yield: 56.0%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 111-46-6
diethylene glycol

: 149299-82-1
tert-butyl 2-(2-(2-hydroxyethoxy)ethoxy)acetate

Guidance literature:: diethylene glycol; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 2h; Inert atmosphere;

bromoacetic acid tert-butyl ester; In tetrahydrofuran; at 0 ℃; for 12h; Inert atmosphere;