(2RS,4RS,9aSR)-4-(3,4-dimethoxyphenyl)octahydro-2H-quinolizin-2-ol

Base Information

• Chemical Name: (2RS,4RS,9aSR)-4-(3,4-dimethoxyphenyl)octahydro-2H-quinolizin-2-ol
• CAS No.: 88931-04-8
• Molecular Formula: C₁₇H₂₅NO₃
• Molecular Weight: 291.39
• Mol file: 88931-04-8.mol

Synonyms:(2RS,4RS,9aSR)-4-(3,4-dimethoxyphenyl)octahydro-2H-quinolizin-2-ol

Chemical Property of (2RS,4RS,9aSR)-4-(3,4-dimethoxyphenyl)octahydro-2H-quinolizin-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2RS,4RS,9aSR)-4-(3,4-dimethoxyphenyl)octahydro-2H-quinolizin-2-ol

There total 29 articles about (2RS,4RS,9aSR)-4-(3,4-dimethoxyphenyl)octahydro-2H-quinolizin-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(4S*,9aR*)-4-(3,4-dimethoxyphenyl)octahydro-2H-quinolizin-2-one (89690-19-7,71593-15-2,89690-20-0,112840-40-1,144409-60-9) → (2RS,4RS,9aSR)-4-(3,4-dimethoxyphenyl)octahydro-2H-quinolizin-2-ol (88931-04-8)

Guidance literature:

With sodium tetrahydroborate; In methanol; for 15h; Ambient temperature;

DOI:10.1021/jo00185a012

Reference yield: 78.0%

(6R,8R,9aS)-6-(3,4-Dimethoxy-phenyl)-8-hydroxy-octahydro-quinolizin-4-one → (2RS,4RS,9aSR)-4-(3,4-dimethoxyphenyl)octahydro-2H-quinolizin-2-ol (88931-04-8)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 2h; Heating;

Reference yield: 74.0%

(4S,9aR)-4-(3,4-dimethoxyphenyl)octahydro-2H-quinolizin-2-one (144409-60-9) → (-)-Lasubine I (68622-77-5,68681-73-2,71656-68-3,88931-04-8,88931-05-9,89771-49-3,149563-95-1)

Guidance literature:

With L-Selectride;

DOI:10.1021/jo00048a003

upstream raw materials:

(4S,9aR)-4-(3,4-dimethoxyphenyl)octahydro-2H-quinolizin-2-one

4-methoxy-3-(trisopropylsilyl)pyridine

4-lithio-1,2-dimethoxybenzene

4-Methoxy-1-[(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyloxycarbonyl]-3-triisopropylsilanyl-pyridinium; chloride

Downstream raw materials:

(+/-)-subcosine I

Acetic acid (2R,4R,9aS)-4-(3,4-dimethoxy-phenyl)-octahydro-quinolizin-2-yl ester

2,2,3-Trichloro-3-(4-methoxy-phenyl)-propionic acid (2S,4S,9aS)-4-(3,4-dimethoxy-phenyl)-octahydro-quinolizin-2-yl ester

(Z)-2-Chloro-3-(4-methoxy-phenyl)-acrylic acid (2S,4S,9aS)-4-(3,4-dimethoxy-phenyl)-octahydro-quinolizin-2-yl ester