1'-{2-(2-trifluoromethylphenoxy)acetyl}spiro(indole-3,4'-piperidine)-2(1H)-one

Base Information

Chemical Name:1'-{2-(2-trifluoromethylphenoxy)acetyl}spiro(indole-3,4'-piperidine)-2(1H)-one
CAS No.:1086061-32-6
Molecular Formula:C₂₁H₁₉F₃N₂O₃
Molecular Weight:404.389
Hs Code.:

Synonyms:1'-{2-(2-trifluoromethylphenoxy)acetyl}spiro(indole-3,4'-piperidine)-2(1H)-one

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Chemical Property of 1'-{2-(2-trifluoromethylphenoxy)acetyl}spiro(indole-3,4'-piperidine)-2(1H)-one

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Technology Process of 1'-{2-(2-trifluoromethylphenoxy)acetyl}spiro(indole-3,4'-piperidine)-2(1H)-one

There total 5 articles about 1'-{2-(2-trifluoromethylphenoxy)acetyl}spiro(indole-3,4'-piperidine)-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.9%

: 252882-61-4
spiro[indoline-3,4'-piperidin]-2-one

: 162922-18-1
2-[2-(trifluoromethyl)phenyloxy]acetic acid

: 1086061-32-6
1'-{2-(2-trifluoromethylphenoxy)acetyl}spiro(indole-3,4'-piperidine)-2(1H)-one

Guidance literature:: 2-(2-(trifluoromethyl)phenoxy)acetic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 1h;

spiro[indoline-3,4'-piperidin]-2-one; With triethylamine; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 444-30-4
2-(trifluoromethyl)phenol

: 1086061-32-6
1'-{2-(2-trifluoromethylphenoxy)acetyl}spiro(indole-3,4'-piperidine)-2(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 15 h / 20 °C

2.1: sodium hydroxide; water / ethanol / 1.5 h / 20 °C

3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

3.2: 1 h / 20 °C

With sodium hydroxide; oxalyl dichloride; water; potassium carbonate; N,N-dimethyl-formamide; In ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 476155-15-4
ethyl 2-(2-(trifluoromethyl)phenoxy)acetate

: 1086061-32-6
1'-{2-(2-trifluoromethylphenoxy)acetyl}spiro(indole-3,4'-piperidine)-2(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide; water / ethanol / 1.5 h / 20 °C

2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

2.2: 1 h / 20 °C

With sodium hydroxide; oxalyl dichloride; water; N,N-dimethyl-formamide; In ethanol; dichloromethane;