(R)-2-(tert-butyldimethylsilyloxy)-4-(1-phenyl-1H-tetrazol-5-ylthio)butanenitrile

Base Information

Chemical Name:(R)-2-(tert-butyldimethylsilyloxy)-4-(1-phenyl-1H-tetrazol-5-ylthio)butanenitrile
CAS No.:1254331-89-9
Molecular Formula:C₁₇H₂₅N₅OSSi
Molecular Weight:375.57
Hs Code.:

Synonyms:(R)-2-(tert-butyldimethylsilyloxy)-4-(1-phenyl-1H-tetrazol-5-ylthio)butanenitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-(tert-butyldimethylsilyloxy)-4-(1-phenyl-1H-tetrazol-5-ylthio)butanenitrile

Chemical Property:

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Technology Process of (R)-2-(tert-butyldimethylsilyloxy)-4-(1-phenyl-1H-tetrazol-5-ylthio)butanenitrile

There total 5 articles about (R)-2-(tert-butyldimethylsilyloxy)-4-(1-phenyl-1H-tetrazol-5-ylthio)butanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1254331-87-7
(R)-4-(1-phenyl-1H-tetrazol-5-ylthio)-2-hydroxybutanenitrile

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1254331-88-8
(S)-2-(tert-butyldimethylsilyloxy)-4-(1-phenyl-1H-tetrazol-5-ylthio)butanenitrile

: 1254331-89-9
(R)-2-(tert-butyldimethylsilyloxy)-4-(1-phenyl-1H-tetrazol-5-ylthio)butanenitrile

Guidance literature:: With 1H-imidazole; In dichloromethane; at 20 ℃; for 18h; optical yield given as %ee;
DOI:10.1021/ol1021417

Reference yield:

: 1254331-73-1
(S)-4-(1-phenyl-1H-tetrazol-5-ylthio)-2-hydroxybutanenitrile

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1254331-88-8
(S)-2-(tert-butyldimethylsilyloxy)-4-(1-phenyl-1H-tetrazol-5-ylthio)butanenitrile

: 1254331-89-9
(R)-2-(tert-butyldimethylsilyloxy)-4-(1-phenyl-1H-tetrazol-5-ylthio)butanenitrile

Guidance literature:: With 1H-imidazole; In dichloromethane; at 20 ℃; for 18h; optical yield given as %ee;
DOI:10.1021/ol1021417

Reference yield:

: 1254331-87-7
(R)-4-(1-phenyl-1H-tetrazol-5-ylthio)-2-hydroxybutanenitrile

: 69739-34-0
t-butyldimethylsiyl triflate

: 1254331-88-8
(S)-2-(tert-butyldimethylsilyloxy)-4-(1-phenyl-1H-tetrazol-5-ylthio)butanenitrile

: 1254331-89-9
(R)-2-(tert-butyldimethylsilyloxy)-4-(1-phenyl-1H-tetrazol-5-ylthio)butanenitrile

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 20 ℃; for 10h; Reagent/catalyst; Overall yield = 84 percent; Overall yield = 139 mg;
DOI:10.1021/acs.joc.8b02033