(R)-4-(1-phenyl-1H-tetrazol-5-ylthio)-2-hydroxybutanenitrile

Base Information

Chemical Name:(R)-4-(1-phenyl-1H-tetrazol-5-ylthio)-2-hydroxybutanenitrile
CAS No.:1254331-87-7
Molecular Formula:C₁₁H₁₁N₅OS
Molecular Weight:261.307
Hs Code.:

Synonyms:(R)-4-(1-phenyl-1H-tetrazol-5-ylthio)-2-hydroxybutanenitrile

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Chemical Property of (R)-4-(1-phenyl-1H-tetrazol-5-ylthio)-2-hydroxybutanenitrile

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Technology Process of (R)-4-(1-phenyl-1H-tetrazol-5-ylthio)-2-hydroxybutanenitrile

There total 2 articles about (R)-4-(1-phenyl-1H-tetrazol-5-ylthio)-2-hydroxybutanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.6%

: 56350-88-0
3-((1-phenyl-1H-tetrazol-5-yl)thio)propanal

: 7677-24-9
trimethylsilyl cyanide

: 1254331-87-7
(R)-4-(1-phenyl-1H-tetrazol-5-ylthio)-2-hydroxybutanenitrile

Guidance literature:: trimethylsilyl cyanide; With titanium(IV) isopropylate; (S)-3-(1H-imidazol-1-yl)-[1,1’-binaphthalene]-2,2’-diol; In dichloromethane; at -50 ℃; for 0.166667h;

3-((1-phenyl-1H-tetrazol-5-yl)thio)propanal; In dichloromethane; at -50 ℃; for 48.5h;

With hydrogenchloride; In dichloromethane; water; at -50 ℃;
DOI:10.1021/ol1021417

Reference yield:

: 86-93-1
1-Phenyl-1H-tetrazole-5-thiol

: 1254331-87-7
(R)-4-(1-phenyl-1H-tetrazol-5-ylthio)-2-hydroxybutanenitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / tetrahydrofuran / 24 h

2.1: t-butyldimethylsiyl triflate; (S)-3-(1H-imidazol-1-yl)-[1,1’-binaphthalene]-2,2’-diol / dichloromethane / 0.17 h / -50 °C

2.2: 48.5 h / -50 °C

With (S)-3-(1H-imidazol-1-yl)-[1,1’-binaphthalene]-2,2’-diol; t-butyldimethylsiyl triflate; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/acs.joc.8b02033