tert-butyl (1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{(tert-butyloxy)carbonyl-3-{(trifluoromethyl)benzyl}amino}propylcarbamate

Base Information

• Chemical Name: tert-butyl (1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{(tert-butyloxy)carbonyl-3-{(trifluoromethyl)benzyl}amino}propylcarbamate
• CAS No.: 674311-03-6
• Molecular Formula: C₂₈H₃₅F₅N₂O₅
• Molecular Weight: 574.588

Synonyms:tert-butyl (1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{(tert-butyloxy)carbonyl-3-{(trifluoromethyl)benzyl}amino}propylcarbamate

Chemical Property of tert-butyl (1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{(tert-butyloxy)carbonyl-3-{(trifluoromethyl)benzyl}amino}propylcarbamate

Chemical Property:

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Technology Process of tert-butyl (1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{(tert-butyloxy)carbonyl-3-{(trifluoromethyl)benzyl}amino}propylcarbamate

There total 1 articles about tert-butyl (1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{(tert-butyloxy)carbonyl-3-{(trifluoromethyl)benzyl}amino}propylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,1-dimethylethyl [(1S,2R)-1-[(3,5-difluorophenyl)methyl]-2-hydroxy-3-({[3-(trifluoromethyl)phenyl]methyl}amino)propyl]-carbamate (597564-19-7) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl (1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{(tert-butyloxy)carbonyl-3-{(trifluoromethyl)benzyl}amino}propylcarbamate (674311-03-6)

Guidance literature:

In tetrahydrofuran; at 0 - 25 ℃; for 18h;

Reference yield:

1-[3-[(dipropylamino)-carbonyl]-5-(1,3-oxazol-2-yl)] benzoic acid (597563-26-3) + tert-butyl (1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{(tert-butyloxy)carbonyl-3-{(trifluoromethyl)benzyl}amino}propylcarbamate (674311-03-6) → (1R,2S)-2-[(tert-butoxycarbonyl)amino]-1-({(tert-butoxycarbonyl)[3-(trifluoromethyl)benzyl]amino}methyl)-3-(3,5-difluorophenyl)propyl-3-[(dipropylamino)carbonyl]-5-(1,3-oxazol-2-yl)benzoate (674311-07-0)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In DMF (N,N-dimethyl-formamide); for 36h;

upstream raw materials:

1,1-dimethylethyl [(1S,2R)-1-[(3,5-difluorophenyl)methyl]-2-hydroxy-3-({[3-(trifluoromethyl)phenyl]methyl}amino)propyl]-carbamate

di-tert-butyl dicarbonate

Downstream raw materials:

(1R,2S)-2-[(tert-butoxycarbonyl)amino]-1-({(tert-butoxycarbonyl)[3-(trifluoromethyl)benzyl]amino}methyl)-3-(3,5-difluorophenyl)propyl-3-[(dipropylamino)carbonyl]-5-(1,3-oxazol-2-yl)benzoate

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