Carbamic acid, [(1S,2R)-1-[(3,5-difluorophenyl)methyl]-2-hydroxy-3-[[[3-(trifluoromethyl) phenyl]methyl]amino]propyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:Carbamic acid, [(1S,2R)-1-[(3,5-difluorophenyl)methyl]-2-hydroxy-3-[[[3-(trifluoromethyl) phenyl]methyl]amino]propyl]-, 1,1-dimethylethyl ester
CAS No.:597564-19-7
Molecular Formula:C23H27F5N2O3
Molecular Weight:474.471
Hs Code.:

Carbamic acid,
[(1S,2R)-1-[(3,5-difluorophenyl)methyl]-2-hydroxy-3-[[[3-(trifluoromethyl)
phenyl]methyl]amino]propyl]-, 1,1-dimethylethyl ester

Synonyms:

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Chemical Property of Carbamic acid, [(1S,2R)-1-[(3,5-difluorophenyl)methyl]-2-hydroxy-3-[[[3-(trifluoromethyl) phenyl]methyl]amino]propyl]-, 1,1-dimethylethyl ester

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Technology Process of Carbamic acid, [(1S,2R)-1-[(3,5-difluorophenyl)methyl]-2-hydroxy-3-[[[3-(trifluoromethyl) phenyl]methyl]amino]propyl]-, 1,1-dimethylethyl ester

There total 2 articles about Carbamic acid, [(1S,2R)-1-[(3,5-difluorophenyl)methyl]-2-hydroxy-3-[[[3-(trifluoromethyl) phenyl]methyl]amino]propyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 388071-27-0
tert-butyl (1S)-2-(3,5-difluorophenyl)-1-[(2S)-oxiranyl]ethylcarbamate

: 2740-83-2
3-(TRIFLUOROMETHYL)BENZYLAMINE

: 597564-19-7
1,1-dimethylethyl [(1S,2R)-1-[(3,5-difluorophenyl)methyl]-2-hydroxy-3-({[3-(trifluoromethyl)phenyl]methyl}amino)propyl]-carbamate

Guidance literature:: With trifluoromethylsulfonimide lithium salt; In 1,1-dichloroethane; at 20 - 50 ℃; for 64h;

Reference yield:

: 597564-19-7
1,1-dimethylethyl [(1S,2R)-1-[(3,5-difluorophenyl)methyl]-2-hydroxy-3-({[3-(trifluoromethyl)phenyl]methyl}amino)propyl]-carbamate

Guidance literature:

Reference yield:

: 597564-19-7
1,1-dimethylethyl [(1S,2R)-1-[(3,5-difluorophenyl)methyl]-2-hydroxy-3-({[3-(trifluoromethyl)phenyl]methyl}amino)propyl]-carbamate

: 388075-42-1
(2R,3S)-3-amino-4-(3,5-difluorophenyl)-1-{[3-(trifluoromethyl)-benzyl]amino}butan-2-ol

Guidance literature:: 1,1-dimethylethyl [(1S,2R)-1-[(3,5-difluorophenyl)methyl]-2-hydroxy-3-({[3-(trifluoromethyl)phenyl]methyl}amino)propyl]-carbamate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

With sodium hydrogencarbonate; In water; ethyl acetate;