4-methoxybenzyl ((1R,2R)-1-((tert-butyldimethylsilyl)oxy)-1-(6-chloropyridin-3-yl)-6-(4-nitrophenyl)-5-oxohexan-2-yl)carbamate

Base Information

Chemical Name:4-methoxybenzyl ((1R,2R)-1-((tert-butyldimethylsilyl)oxy)-1-(6-chloropyridin-3-yl)-6-(4-nitrophenyl)-5-oxohexan-2-yl)carbamate
CAS No.:1190615-02-1
Molecular Formula:C₃₂H₄₀ClN₃O₇Si
Molecular Weight:642.224
Hs Code.:

Synonyms:4-methoxybenzyl ((1R,2R)-1-((tert-butyldimethylsilyl)oxy)-1-(6-chloropyridin-3-yl)-6-(4-nitrophenyl)-5-oxohexan-2-yl)carbamate

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Chemical Property of 4-methoxybenzyl ((1R,2R)-1-((tert-butyldimethylsilyl)oxy)-1-(6-chloropyridin-3-yl)-6-(4-nitrophenyl)-5-oxohexan-2-yl)carbamate

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Technology Process of 4-methoxybenzyl ((1R,2R)-1-((tert-butyldimethylsilyl)oxy)-1-(6-chloropyridin-3-yl)-6-(4-nitrophenyl)-5-oxohexan-2-yl)carbamate

There total 8 articles about 4-methoxybenzyl ((1R,2R)-1-((tert-butyldimethylsilyl)oxy)-1-(6-chloropyridin-3-yl)-6-(4-nitrophenyl)-5-oxohexan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1190615-01-0
4-methoxybenzyl ((1R,2R)-1-((tert-butyldimethylsilyl)oxy)-1-(6-chloropyridin-3-yl)-6-(4-nitrophenyl)hex-5-yn-2-yl)carbamate

: 1190615-02-1
4-methoxybenzyl ((1R,2R)-1-((tert-butyldimethylsilyl)oxy)-1-(6-chloropyridin-3-yl)-6-(4-nitrophenyl)-5-oxohexan-2-yl)carbamate

Guidance literature:: 4-methoxybenzyl ((1R,2R)-1-((tert-butyldimethylsilyl)oxy)-1-(6-chloropyridin-3-yl)-6-(4-nitrophenyl)hex-5-yn-2-yl)carbamate; With pyrrolidine; In N,N-dimethyl-formamide; at 80 ℃; for 5h;

With water; acetic acid; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield:

: 1190614-98-2
(R)-2-((S)-(6-chloropyridin-3-yl)((trimethylsilyl)oxy)methyl)hex-5-ynoic acid

: 1190615-02-1
4-methoxybenzyl ((1R,2R)-1-((tert-butyldimethylsilyl)oxy)-1-(6-chloropyridin-3-yl)-6-(4-nitrophenyl)-5-oxohexan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; diphenyl phosphoryl azide / toluene / 6 h / 20 °C / Inert atmosphere

1.2: 16 h / 100 °C / Inert atmosphere

2.1: copper(l) iodide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile / 0.25 h / 20 °C / Inert atmosphere

2.2: 15 h / 20 °C / Inert atmosphere

3.1: pyrrolidine / N,N-dimethyl-formamide / 5 h / 80 °C / Inert atmosphere

3.2: 3 h / 20 °C

With pyrrolidine; copper(l) iodide; diphenyl phosphoryl azide; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 1190614-96-0
(S)-4-benzyl-3-((R)-2-((S)-(6-chloropyridin-3-yl)(hydroxy)methyl)hex-5-ynoyl)oxazolidin-2-one

: 1190615-02-1
4-methoxybenzyl ((1R,2R)-1-((tert-butyldimethylsilyl)oxy)-1-(6-chloropyridin-3-yl)-6-(4-nitrophenyl)-5-oxohexan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 2,6-dimethylpyridine / dichloromethane / 16 h / 0 - 3 °C / Inert atmosphere

2.1: sodium hydroxide; dihydrogen peroxide / water; tetrahydrofuran / 18 h / 0 - 5 °C / Inert atmosphere

2.2: 0 - 15 °C

2.3: 0 °C / pH 3

3.1: triethylamine; diphenyl phosphoryl azide / toluene / 6 h / 20 °C / Inert atmosphere

3.2: 16 h / 100 °C / Inert atmosphere

4.1: copper(l) iodide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile / 0.25 h / 20 °C / Inert atmosphere

4.2: 15 h / 20 °C / Inert atmosphere

5.1: pyrrolidine / N,N-dimethyl-formamide / 5 h / 80 °C / Inert atmosphere

5.2: 3 h / 20 °C

With pyrrolidine; 2,6-dimethylpyridine; copper(l) iodide; diphenyl phosphoryl azide; dihydrogen peroxide; triethylamine; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;