phenylalanine methyl ester tosylate

Base Information

• Chemical Name: phenylalanine methyl ester tosylate
• CAS No.: 67436-23-1
• Molecular Formula: C₇H₈O₃S*C₁₀H₁₃NO₂
• Molecular Weight: 351.423
• Mol file: 67436-23-1.mol

Synonyms:phenylalanine methyl ester tosylate

Chemical Property of phenylalanine methyl ester tosylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of phenylalanine methyl ester tosylate

There total 1 articles about phenylalanine methyl ester tosylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) + toluene-4-sulfonic acid (104-15-4) → phenylalanine methyl ester tosylate (67436-23-1)

Guidance literature:

In benzene; Heating;

DOI:10.1055/s-1997-1374

Reference yield: 94.0%

9-chloro-9-phenyl-9H-fluorene (25022-99-5) + phenylalanine methyl ester tosylate (67436-23-1) → methyl (S)-3-phenyl-2-[(9-phenyl-9H-fluoren-9-yl)amino]propanoate

Guidance literature:

With 4-methyl-morpholine; silver nitrate; In acetonitrile; at 0 - 20 ℃; for 0.5h;

DOI:10.1021/acs.joc.9b02809

Reference yield: 73.0%

(S)-Mandelic acid (17199-29-0) + phenylalanine methyl ester tosylate (67436-23-1) → (R)-N-(hydroxyphenylacetyl)-(S)-phenylalanine methyl ester (79546-49-9)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1.) 0 deg C, 1 h, 2.) room temperature;

DOI:10.1016/0022-328X(89)87285-7

upstream raw materials:

methanol

L-phenylalanine

toluene-4-sulfonic acid

Downstream raw materials:

N-(phenylglyoxyl)-(S)-α-phenylalanine methyl ester

(R)-N-(hydroxyphenylacetyl)-(S)-phenylalanine methyl ester

Z-Glu(OtBu)-Phe-OMe

N-(pyruvoyl)-(S)-α-phenylalanine methyl ester

Refernces