2-Morpholino-1-phenylethanol

Base Information

• Chemical Name: 2-Morpholino-1-phenylethanol
• CAS No.: 4432-34-2
• Molecular Formula: C12H17 N O2
• Molecular Weight: 207.272
• Hs Code.: 2934999090
• European Community (EC) Number: 654-449-8
• NSC Number: 400611
• DSSTox Substance ID: DTXSID301034887
• Nikkaji Number: J41.780G
• ChEMBL ID: CHEMBL1897032
• Mol file: 4432-34-2.mol

Synonyms:2-Morpholino-1-phenylethanol;4432-34-2;2-morpholin-4-yl-1-phenylethanol;alpha-Phenyl-4-morpholineethanol;4-Morpholineethanol, .alpha.-phenyl-;4-MORPHOLINEETHANOL, alpha-PHENYL-;1-(beta-Hydroxyphenethyl)morpholine;NSC 400611;BRN 0172769;Benzyl alcohol, alpha-(morpholinomethyl)-;Benzenemethanol, alpha-(4-morpholinylmethyl)-;Benzenemethanol, .alpha.-(4-morpholinylmethyl)-;.alpha.-Phenyl-4-morpholineethanol;1-(.beta.-Hydroxyphenethyl)morpholine;Benzyl alcohol, .alpha.-(morpholinomethyl)-;4-27-00-00160 (Beilstein Handbook Reference);NSC400611;Maybridge4_001705;Oprea1_540474;1-Phenyl-2-morpholinoethanol;2-morpholino-1-phenyl-ethanol;RUBIDIUMTETRAFLUOROBORATE;SCHEMBL1460360;C(O)(CN1CCOCC1)c2ccccc2;CHEMBL1897032;WLN: T6N DOTJ AYR&1Q;2-morpholino-1-phenyl-1-ethanol;2-Morpholino-1-phenylethan-1-ol;CHEBI:190664;DTXSID301034887;HMS1525N11;2-(4-Morpholinyl)-1-phenylethanol;MFCD00023377;ZB0051;AKOS001016770;AKOS016050351;2-(4-Morpholinyl)-1-phenylethanol #;NSC-400611;IDI1_032287;NCGC00184356-01;NCGC00184356-02;LS-92971;CS-0327287;FT-0635294;EC-000.2073;BRD-A88790041-001-01-7;Z31371829

Chemical Property of 2-Morpholino-1-phenylethanol

Chemical Property:

• Vapor Pressure: 2.98E-05mmHg at 25°C
• Boiling Point: 342°C at 760 mmHg
• Flash Point: 160.6°C
• PSA: 32.70000
• Density: 1.119g/cm³
• LogP: 0.99010
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 207.125928785
• Heavy Atom Count: 15
• Complexity: 175

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1CC(C2=CC=CC=C2)O

Technology Process of 2-Morpholino-1-phenylethanol

There total 14 articles about 2-Morpholino-1-phenylethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

morpholine (110-91-8,99108-56-2) + styrene oxide (96-09-3) → 2-morpholino-1-phenylethanol (4432-34-2)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; 1.) 0 deg C, 15 min; 25 deg C, 45 min, 2.) 25 deg C, 3 h;

DOI:10.1021/jo00104a034

Reference yield: 90.0%

morpholine (110-91-8,99108-56-2) + phenylethane 1,2-diol (93-56-1) → 2-morpholino-1-phenylethanol (4432-34-2)

Guidance literature:

With [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; bis[2-(diphenylphosphino)phenyl] ether; at 115 ℃; for 2h; Inert atmosphere; Microwave irradiation; Neat (no solvent);

DOI:10.1021/jo102521a

Reference yield: 88.0%

4-morpholinylacetophenone (779-53-3) → 2-morpholino-1-phenylethanol (4432-34-2)

Guidance literature:

With formic acid; 4-methoxy-N-(1-(naphthalen-2-yl)ethylidene)aniline; sodium formate; In water; at 80 ℃; for 18h; pH=4.5; chemoselective reaction; Inert atmosphere;

DOI:10.1002/chem.201403701

upstream raw materials:

morpholine

styrene oxide

ethanol

2-morpholino-1-phenyl-ethanone; hydrochloride

Downstream raw materials:

2-naphthalen-1-yl-propionic acid 2-morpholin-4-yl-1-phenyl-ethyl ester

2-naphthalen-1-yl-butyric acid 2-morpholin-4-yl-1-phenyl-ethyl ester

4-(2-phenoxaborin-10-yloxy-2-phenyl-ethyl)-morpholine

1-Phenyl-2-morpholino-ethanol-(1)-methoiodid