(R)-tert-butyl 4-(2-fluoro-4-(5-((4-(13-(5-methyl-2,4-dioxo-3,4-dihydro pyrimidin-1(2H)-yl)-2,5,8,11-tetraoxatridecyl)-1H-1,2,3-triazol-1-yl)methyl)-2-oxazolidin-3-yl)phenyl)piperazine-1-carboxylate

Base Information

• Chemical Name: (R)-tert-butyl 4-(2-fluoro-4-(5-((4-(13-(5-methyl-2,4-dioxo-3,4-dihydro pyrimidin-1(2H)-yl)-2,5,8,11-tetraoxatridecyl)-1H-1,2,3-triazol-1-yl)methyl)-2-oxazolidin-3-yl)phenyl)piperazine-1-carboxylate
• CAS No.: 1308299-18-4
• Molecular Formula: C₃₅H₄₉FN₈O₁₀
• Molecular Weight: 760.82
• Mol file: 1308299-18-4.mol

Synonyms:(R)-tert-butyl 4-(2-fluoro-4-(5-((4-(13-(5-methyl-2,4-dioxo-3,4-dihydro pyrimidin-1(2H)-yl)-2,5,8,11-tetraoxatridecyl)-1H-1,2,3-triazol-1-yl)methyl)-2-oxazolidin-3-yl)phenyl)piperazine-1-carboxylate

Chemical Property of (R)-tert-butyl 4-(2-fluoro-4-(5-((4-(13-(5-methyl-2,4-dioxo-3,4-dihydro pyrimidin-1(2H)-yl)-2,5,8,11-tetraoxatridecyl)-1H-1,2,3-triazol-1-yl)methyl)-2-oxazolidin-3-yl)phenyl)piperazine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-tert-butyl 4-(2-fluoro-4-(5-((4-(13-(5-methyl-2,4-dioxo-3,4-dihydro pyrimidin-1(2H)-yl)-2,5,8,11-tetraoxatridecyl)-1H-1,2,3-triazol-1-yl)methyl)-2-oxazolidin-3-yl)phenyl)piperazine-1-carboxylate

There total 5 articles about (R)-tert-butyl 4-(2-fluoro-4-(5-((4-(13-(5-methyl-2,4-dioxo-3,4-dihydro pyrimidin-1(2H)-yl)-2,5,8,11-tetraoxatridecyl)-1H-1,2,3-triazol-1-yl)methyl)-2-oxazolidin-3-yl)phenyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

(S)-N-[3-[3-fluoro-4-[N-t-butoxycarbonylpiperazin-1-yl]phenyl]-2-oxooxazolidin-5-ylmethyl]azide (154590-64-4) + 5-methyl-1-(3,6,9,12-tetraoxapentadec-14-ynyl)pyrimidine-2,4(1H,3H)-dione (1308299-11-7) → (R)-tert-butyl 4-(2-fluoro-4-(5-((4-(13-(5-methyl-2,4-dioxo-3,4-dihydro pyrimidin-1(2H)-yl)-2,5,8,11-tetraoxatridecyl)-1H-1,2,3-triazol-1-yl)methyl)-2-oxazolidin-3-yl)phenyl)piperazine-1-carboxylate (1308299-18-4)

Guidance literature:

With copper(l) iodide; triethylamine; In acetonitrile; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.2174/157340611794072670

Reference yield:

3,6,9,12-tetraoxapentadec-14-yn-1-ol (87450-10-0) → (R)-tert-butyl 4-(2-fluoro-4-(5-((4-(13-(5-methyl-2,4-dioxo-3,4-dihydro pyrimidin-1(2H)-yl)-2,5,8,11-tetraoxatridecyl)-1H-1,2,3-triazol-1-yl)methyl)-2-oxazolidin-3-yl)phenyl)piperazine-1-carboxylate (1308299-18-4)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine / dichloromethane / 0 - 20 °C

2: potassium bromide / N,N-dimethyl-formamide / 100 °C

3: potassium carbonate / N,N-dimethyl-formamide / 100 °C

4: copper(l) iodide; triethylamine / acetonitrile / 2 h / 20 °C / Inert atmosphere

With pyridine; copper(l) iodide; potassium carbonate; triethylamine; potassium bromide; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.2174/157340611794072670

Reference yield:

Tetraethylene glycol (112-60-7) → (R)-tert-butyl 4-(2-fluoro-4-(5-((4-(13-(5-methyl-2,4-dioxo-3,4-dihydro pyrimidin-1(2H)-yl)-2,5,8,11-tetraoxatridecyl)-1H-1,2,3-triazol-1-yl)methyl)-2-oxazolidin-3-yl)phenyl)piperazine-1-carboxylate (1308299-18-4)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium hydride / 1,4-dioxane; toluene; mineral oil / 20 °C

2: pyridine / dichloromethane / 0 - 20 °C

3: potassium bromide / N,N-dimethyl-formamide / 100 °C

4: potassium carbonate / N,N-dimethyl-formamide / 100 °C

5: copper(l) iodide; triethylamine / acetonitrile / 2 h / 20 °C / Inert atmosphere

With pyridine; copper(l) iodide; sodium hydride; potassium carbonate; triethylamine; potassium bromide; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil;

DOI:10.2174/157340611794072670

upstream raw materials:

(S)-N-[3-[3-fluoro-4-[N-t-butoxycarbonylpiperazin-1-yl]phenyl]-2-oxooxazolidin-5-ylmethyl]azide

5-methyl-1-(3,6,9,12-tetraoxapentadec-14-ynyl)pyrimidine-2,4(1H,3H)-dione

toluene-4-sulfonic acid 2-{2-[2-(2-ethynyloxyethoxy)-ethoxy]-ethoxy}-ethyl ester

triethylene glycol 2-bromoethyl propargyl ether