3-azido-5-O-tert-butyldiphenylsilyl-2,3-dideoxy-D-erythro-pentose propan-1,3-diyl dithioacetal

Base Information

Chemical Name:3-azido-5-O-tert-butyldiphenylsilyl-2,3-dideoxy-D-erythro-pentose propan-1,3-diyl dithioacetal
CAS No.:250279-57-3
Molecular Formula:C₂₄H₃₃N₃O₂S₂Si
Molecular Weight:487.762
Hs Code.:

Synonyms:3-azido-5-O-tert-butyldiphenylsilyl-2,3-dideoxy-D-erythro-pentose propan-1,3-diyl dithioacetal

Suppliers and Price of 3-azido-5-O-tert-butyldiphenylsilyl-2,3-dideoxy-D-erythro-pentose propan-1,3-diyl dithioacetal

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-azido-5-O-tert-butyldiphenylsilyl-2,3-dideoxy-D-erythro-pentose propan-1,3-diyl dithioacetal

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-azido-5-O-tert-butyldiphenylsilyl-2,3-dideoxy-D-erythro-pentose propan-1,3-diyl dithioacetal

There total 1 articles about 3-azido-5-O-tert-butyldiphenylsilyl-2,3-dideoxy-D-erythro-pentose propan-1,3-diyl dithioacetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 109-80-8
1.3-propanedithiol

: 114071-63-5
methyl 3-azido-5-O-tert-butyldiphenylsilyl-2,3-dideoxy-α-D-erythro-pentofuranoside

: 250279-57-3
3-azido-5-O-tert-butyldiphenylsilyl-2,3-dideoxy-D-erythro-pentose propan-1,3-diyl dithioacetal

Guidance literature:: With boron trifluoride diethyl etherate; In 1,2-dichloro-ethane; at 50 ℃; for 1.16667h;
DOI:10.1016/S0008-6215(99)00126-3

Reference yield: 77.0%

: 100-39-0
benzyl bromide

: 250279-57-3
3-azido-5-O-tert-butyldiphenylsilyl-2,3-dideoxy-D-erythro-pentose propan-1,3-diyl dithioacetal

: 250279-58-4
3-azido-4-O-benzyl-5-O-tert-butyldiphenylsilyl-2,3-dideoxy-D-erythro-pentose propane-1,3-diyl dithioacetal

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 4h;
DOI:10.1016/S0008-6215(99)00126-3

Reference yield:

: 250279-57-3
3-azido-5-O-tert-butyldiphenylsilyl-2,3-dideoxy-D-erythro-pentose propan-1,3-diyl dithioacetal

: (4S,5S,6R)-4-Azido-5-benzyloxy-6-trifluoromethyl-tetrahydro-pyran-2-ol

Guidance literature:: Multi-step reaction with 8 steps

1.1: 77 percent / NaH (in oil) / dimethylformamide / 4 h / 0 °C

2.1: 85 percent / Bu₄NF*3H₂O / various solvent(s) / 1.5 h / 20 °C

3.1: (COCl)2; DMSO / CH₂Cl₂ / 0.67 h / -78 °C

3.2: 3.08 g / ethyldiisopropylamine / CH₂Cl₂ / 2 h / -78 - 0 °C

4.1: Bu₄NF*3H₂O / various solvent(s) / 0.17 h / -40 °C

5.1: Bu₄NF*3H₂O / various solvent(s) / 0.17 h / 0 °C

6.1: 593 mg / pyridine / CH₂Cl₂ / 1 h / 0 °C

7.1: 38 percent / NaNO₂; 15-crown-5 / dimethylformamide / 4 h / 20 °C

8.1: 1.51 g / CaCO₃; Hg(ClO₄)2*3H₂O / H₂O; various solvent(s) / 1 h / 20 °C

With pyridine; mercury(II) perchlorate; oxalyl dichloride; 15-crown-5; tetrabutyl ammonium fluoride; sodium hydride; dimethyl sulfoxide; calcium carbonate; sodium nitrite; In dichloromethane; water; N,N-dimethyl-formamide; 1.1: Etherification / 2.1: Substitution / 3.1: Swern oxidation / 3.2: Hydrolysis / 4.1: Addition / 5.1: desilylation / 6.1: Esterification / 7.1: Substitution / 8.1: Cyclization;
DOI:10.1016/S0008-6215(99)00126-3