[N-(benzyloxycarbonyl)glutamyl-γ-methyl ester]seryl-O-[O,O-dimethylphosphoryl]alanine ethyl ester

Base Information

Chemical Name:[N-(benzyloxycarbonyl)glutamyl-γ-methyl ester]seryl-O-[O,O-dimethylphosphoryl]alanine ethyl ester
CAS No.:153841-70-4
Molecular Formula:C₂₄H₃₆N₃O₁₂P
Molecular Weight:589.537
Hs Code.:

Synonyms:[N-(benzyloxycarbonyl)glutamyl-γ-methyl ester]seryl-O-[O,O-dimethylphosphoryl]alanine ethyl ester

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Chemical Property of [N-(benzyloxycarbonyl)glutamyl-γ-methyl ester]seryl-O-[O,O-dimethylphosphoryl]alanine ethyl ester

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Technology Process of [N-(benzyloxycarbonyl)glutamyl-γ-methyl ester]seryl-O-[O,O-dimethylphosphoryl]alanine ethyl ester

There total 6 articles about [N-(benzyloxycarbonyl)glutamyl-γ-methyl ester]seryl-O-[O,O-dimethylphosphoryl]alanine ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 21026-97-1
N-(benzyloxycarbonyl)serylalanine ethyl ester

: 153841-70-4
[N-(benzyloxycarbonyl)glutamyl-γ-methyl ester]seryl-O-[O,O-dimethylphosphoryl]alanine ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 72 percent / H₂ / 10 percent Pd/C / ethanol / 4 h

2: 56 percent / dicyclohexylcarbodiimide / CH₂Cl₂ / 4 h / 0 °C

3: tetrazole / CH₂Cl₂ / 1 h / 20 °C

4: m-CPBA / CH₂Cl₂ / 1 h / 20 °C

With 1H-tetrazole; hydrogen; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide; palladium on activated charcoal; In ethanol; dichloromethane; 1: Hydrogenolysis / 2: Condensation / 3: phosphitylation / 4: Oxidation;
DOI:10.1021/tx960097w

Reference yield:

: (S)-4-Benzyloxycarbonylamino-4-[(S)-2-(dimethoxy-phosphanyloxy)-1-((S)-1-ethoxycarbonyl-ethylcarbamoyl)-ethylcarbamoyl]-butyric acid methyl ester

: 153841-70-4
[N-(benzyloxycarbonyl)glutamyl-γ-methyl ester]seryl-O-[O,O-dimethylphosphoryl]alanine ethyl ester

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/tx960097w

Reference yield:

: 4652-65-7
(S)-2-Benzyloxycarbonylamino-pentanedioic acid 5-methyl ester

: 153841-70-4
[N-(benzyloxycarbonyl)glutamyl-γ-methyl ester]seryl-O-[O,O-dimethylphosphoryl]alanine ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 56 percent / dicyclohexylcarbodiimide / CH₂Cl₂ / 4 h / 0 °C

2: tetrazole / CH₂Cl₂ / 1 h / 20 °C

3: m-CPBA / CH₂Cl₂ / 1 h / 20 °C

With 1H-tetrazole; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide; In dichloromethane; 1: Condensation / 2: phosphitylation / 3: Oxidation;
DOI:10.1021/tx960097w