Technology Process of (2R,3R,4R)-1-azido-2,3,4,6-tetra(benzyloxy)-4-(trityloxymethyl)hexane
There total 12 articles about (2R,3R,4R)-1-azido-2,3,4,6-tetra(benzyloxy)-4-(trityloxymethyl)hexane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(2R,3R,4R)-1-azido-2,4,6-tris(benzyloxy)-4-(trityloxymethyl)hexan-3-ol;
With
sodium hydride;
In
N,N-dimethyl-formamide; mineral oil;
at 0 ℃;
for 0.5h;
benzyl bromide;
In
N,N-dimethyl-formamide; mineral oil;
at 0 - 20 ℃;
DOI:10.1016/j.tetasy.2010.11.027
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: sodium tetrahydroborate / methanol / 2 h / 0 - 20 °C
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C
2.2: 0 - 20 °C
3.1: silica supported perchloric acid / methanol / 3 h / 20 °C
4.1: dmap; triethylamine / dichloromethane / 1 h / 0 °C
5.1: sodium azide / N,N-dimethyl-formamide / 3 h / 120 °C
6.1: water; trifluoroacetic acid / 1 h / 20 °C
6.2: 0 - 20 °C
7.1: sodium tetrahydroborate / methanol / 0 - 20 °C
8.1: dmap; triethylamine / dichloromethane / 0 - 20 °C
9.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C
9.2: 0 - 20 °C
With
dmap; sodium tetrahydroborate; sodium azide; silica supported perchloric acid; water; sodium hydride; triethylamine; trifluoroacetic acid;
In
methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.tetasy.2010.11.027
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C
1.2: 0 - 20 °C
2.1: silica supported perchloric acid / methanol / 3 h / 20 °C
3.1: dmap; triethylamine / dichloromethane / 1 h / 0 °C
4.1: sodium azide / N,N-dimethyl-formamide / 3 h / 120 °C
5.1: water; trifluoroacetic acid / 1 h / 20 °C
5.2: 0 - 20 °C
6.1: sodium tetrahydroborate / methanol / 0 - 20 °C
7.1: dmap; triethylamine / dichloromethane / 0 - 20 °C
8.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C
8.2: 0 - 20 °C
With
dmap; sodium tetrahydroborate; sodium azide; silica supported perchloric acid; water; sodium hydride; triethylamine; trifluoroacetic acid;
In
methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.tetasy.2010.11.027
