(R)-1-((3aR,5R,6R,6aR)-6-(benzyloxy)-6-(2-hydroxyethyl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)-2-(trityloxy)ethanol

Base Information

Chemical Name:(R)-1-((3aR,5R,6R,6aR)-6-(benzyloxy)-6-(2-hydroxyethyl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)-2-(trityloxy)ethanol
CAS No.:1271332-66-1
Molecular Formula:C₃₇H₄₀O₇
Molecular Weight:596.72
Hs Code.:

Synonyms:(R)-1-((3aR,5R,6R,6aR)-6-(benzyloxy)-6-(2-hydroxyethyl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)-2-(trityloxy)ethanol

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Chemical Property of (R)-1-((3aR,5R,6R,6aR)-6-(benzyloxy)-6-(2-hydroxyethyl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)-2-(trityloxy)ethanol

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Technology Process of (R)-1-((3aR,5R,6R,6aR)-6-(benzyloxy)-6-(2-hydroxyethyl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)-2-(trityloxy)ethanol

There total 4 articles about (R)-1-((3aR,5R,6R,6aR)-6-(benzyloxy)-6-(2-hydroxyethyl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)-2-(trityloxy)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₇H₃₈O₇

: 1271332-66-1
(R)-1-((3aR,5R,6R,6aR)-6-(benzyloxy)-6-(2-hydroxyethyl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)-2-(trityloxy)ethanol

Guidance literature:: C₃₇H₃₈O₇; With sodium tetrahydroborate; In methanol; at 0 - 20 ℃; for 2h;

With ammonium chloride; In methanol; water;
DOI:10.1016/j.tetasy.2010.11.027

Reference yield:

: 1271332-59-2
(R)-1-((3aR,5R,6R,6aR)-6-allyl-6-(benzyloxy)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)-2-(trityloxy)ethanol

: 1271332-66-1
(R)-1-((3aR,5R,6R,6aR)-6-(benzyloxy)-6-(2-hydroxyethyl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)-2-(trityloxy)ethanol

Guidance literature:: Multi-step reaction with 3 steps

1: osmium(VIII) oxide; water; 4-methylmorpholine N-oxide / acetone; tert-butyl alcohol / 12 h / 20 °C

2: sodium periodate / methanol; water / 0 - 20 °C

3: sodium tetrahydroborate / methanol / 2 h / 0 - 20 °C

With sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; water; 4-methylmorpholine N-oxide; In methanol; water; acetone; tert-butyl alcohol;
DOI:10.1016/j.tetasy.2010.11.027

Reference yield:

: 76-83-5
trityl chloride

: 1271332-66-1
(R)-1-((3aR,5R,6R,6aR)-6-(benzyloxy)-6-(2-hydroxyethyl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)-2-(trityloxy)ethanol

Guidance literature:: Multi-step reaction with 4 steps

1: dmap; triethylamine / dichloromethane / 0 - 20 °C

2: osmium(VIII) oxide; water; 4-methylmorpholine N-oxide / acetone; tert-butyl alcohol / 12 h / 20 °C

3: sodium periodate / methanol; water / 0 - 20 °C

4: sodium tetrahydroborate / methanol / 2 h / 0 - 20 °C

With dmap; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; water; 4-methylmorpholine N-oxide; triethylamine; In methanol; dichloromethane; water; acetone; tert-butyl alcohol;
DOI:10.1016/j.tetasy.2010.11.027