4-(1,3-dihydro-3-ethyl-1-methyl-2-oxo-2H-imidazo[4,5-g]quinazolin-8-yl)-1-piperazinecarboxylic acid tert-butyl ester

Base Information

Chemical Name:4-(1,3-dihydro-3-ethyl-1-methyl-2-oxo-2H-imidazo[4,5-g]quinazolin-8-yl)-1-piperazinecarboxylic acid tert-butyl ester
CAS No.:205264-32-0
Molecular Formula:C₂₁H₂₈N₆O₃
Molecular Weight:412.492
Hs Code.:

Synonyms:4-(1,3-dihydro-3-ethyl-1-methyl-2-oxo-2H-imidazo[4,5-g]quinazolin-8-yl)-1-piperazinecarboxylic acid tert-butyl ester

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Chemical Property of 4-(1,3-dihydro-3-ethyl-1-methyl-2-oxo-2H-imidazo[4,5-g]quinazolin-8-yl)-1-piperazinecarboxylic acid tert-butyl ester

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Technology Process of 4-(1,3-dihydro-3-ethyl-1-methyl-2-oxo-2H-imidazo[4,5-g]quinazolin-8-yl)-1-piperazinecarboxylic acid tert-butyl ester

There total 1 articles about 4-(1,3-dihydro-3-ethyl-1-methyl-2-oxo-2H-imidazo[4,5-g]quinazolin-8-yl)-1-piperazinecarboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 53449-14-2
7-chloro-6-nitro-4(3H)-quinazolinone

: 205264-32-0
4-(1,3-dihydro-3-ethyl-1-methyl-2-oxo-2H-imidazo[4,5-g]quinazolin-8-yl)-1-piperazinecarboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: dimethylsulfoxide / 180 °C

2.1: POCl₃ / Heating

3.1: propan-2-ol / 4 h / Heating

4.1: 92 percent / Et₃N / CH₂Cl₂ / 20 °C

5.1: H₂ / Pd/C / ethanol; H₂O / 6 h / 20 °C

6.1: 100 percent / Et₃N / dimethylformamide / 4.5 h / 80 °C

7.1: NaH / dimethylformamide / 0.5 h / 20 °C

7.2: 51 percent / dimethylformamide / 20 °C

With hydrogen; sodium hydride; triethylamine; trichlorophosphate; palladium on activated charcoal; In ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/jm020505v

Reference yield:

: 205264-32-0
4-(1,3-dihydro-3-ethyl-1-methyl-2-oxo-2H-imidazo[4,5-g]quinazolin-8-yl)-1-piperazinecarboxylic acid tert-butyl ester

: N-Benzyl-4-(1,3-dihydro-3-ethyl-1-methyl-2-oxo-2H-imidazo[4,5-g]quinazolin-8-yl)-1-piperazinethiocarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: CF₃COOH / CH₂Cl₂ / 1.5 h / cooling

2: Et₃N / dimethylformamide / 20 °C

With triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm020505v

Reference yield:

: 205264-32-0
4-(1,3-dihydro-3-ethyl-1-methyl-2-oxo-2H-imidazo[4,5-g]quinazolin-8-yl)-1-piperazinecarboxylic acid tert-butyl ester

: 4-(1,3-Dihydro-3-ethyl-1-methyl-2-oxo-2H-imidazo[4,5-g]quinazolin-8-yl)-N-(4-phenoxyphenyl)-1-piperazinecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: CF₃COOH / CH₂Cl₂ / 1.5 h / cooling

2: Et₃N / dimethylformamide / 20 °C

With triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm020505v