threo-1-(phenoxymethyl)-3,5,6,7,8,8a-hexahydro-1H-oxazolo<3,4-a>pyridine

Base Information

Chemical Name:threo-1-(phenoxymethyl)-3,5,6,7,8,8a-hexahydro-1H-oxazolo<3,4-a>pyridine
CAS No.:115462-57-2
Molecular Formula:C₁₄H₁₉NO₂
Molecular Weight:233.31
Hs Code.:

Synonyms:threo-1-(phenoxymethyl)-3,5,6,7,8,8a-hexahydro-1H-oxazolo<3,4-a>pyridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of threo-1-(phenoxymethyl)-3,5,6,7,8,8a-hexahydro-1H-oxazolo<3,4-a>pyridine

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Technology Process of threo-1-(phenoxymethyl)-3,5,6,7,8,8a-hexahydro-1H-oxazolo<3,4-a>pyridine

There total 4 articles about threo-1-(phenoxymethyl)-3,5,6,7,8,8a-hexahydro-1H-oxazolo<3,4-a>pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 117575-36-7
α-phenoxymethyl-2-piperidinemethanol

: 115462-56-1
erythro-1-(phenoxymethyl)-3,5,6,7,8,8a-hexahydro-1H-oxazolo<3,4-a>pyridine

: 115462-57-2
threo-1-(phenoxymethyl)-3,5,6,7,8,8a-hexahydro-1H-oxazolo<3,4-a>pyridine

Guidance literature:: With potassium hydroxide; In methanol; for 2h; Heating;
DOI:10.1021/jm00119a011

Reference yield:

: 100-69-6,25014-15-7,27476-03-5,329041-71-6
2-vinylpyridine

: 115462-57-2
threo-1-(phenoxymethyl)-3,5,6,7,8,8a-hexahydro-1H-oxazolo<3,4-a>pyridine

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NBS, 2.) Na₂CO₃ / 1.) dioxane-H₂O

2: 58 percent / 1.) sodium hydride / dimethylformamide / 12 h / 60 °C

3: 95 percent / 1.) HCl, 2.) H₂ / 2.) PtO₂ / 1.) ether, 2.) CH₃OH

4: 18 percent / aq. KOH / methanol / 2 h / Heating

With hydrogenchloride; potassium hydroxide; N-Bromosuccinimide; hydrogen; sodium hydride; sodium carbonate; platinum(IV) oxide; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00119a011

Reference yield:

: 55967-94-7,237081-53-7
2-oxiranylpyridine

: 115462-57-2
threo-1-(phenoxymethyl)-3,5,6,7,8,8a-hexahydro-1H-oxazolo<3,4-a>pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: 58 percent / 1.) sodium hydride / dimethylformamide / 12 h / 60 °C

2: 95 percent / 1.) HCl, 2.) H₂ / 2.) PtO₂ / 1.) ether, 2.) CH₃OH

3: 18 percent / aq. KOH / methanol / 2 h / Heating

With hydrogenchloride; potassium hydroxide; hydrogen; sodium hydride; platinum(IV) oxide; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00119a011