Technology Process of 2-[7-(3,5-dimethoxy-benzylamino)-1,1-dioxo-1,3,4,5-tetrahydro-1λ6-benzo[f][1,2,5]thiadiazepin-2-yl]-4-methyl-pentanoic acid
There total 9 articles about 2-[7-(3,5-dimethoxy-benzylamino)-1,1-dioxo-1,3,4,5-tetrahydro-1λ6-benzo[f][1,2,5]thiadiazepin-2-yl]-4-methyl-pentanoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: ethanol / 5 h / 20 °C
2: 104 mg / sodium borohydride / ethanol / 20 °C
3: trifluoroacetic acid / 1.5 h
With
sodium tetrahydroborate; trifluoroacetic acid;
In
ethanol;
DOI:10.1021/jm020475w
- Guidance literature:
-
Multi-step reaction with 7 steps
1: N-methylmorpholine / dioxane / 20 °C
2: diethyl azaodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 °C
3: Fe; aq. acetic acid / 1.5 h / 60 °C
4: N-methylmorpholine / dimethylformamide / 80 °C
5: ethanol / 5 h / 20 °C
6: 104 mg / sodium borohydride / ethanol / 20 °C
7: trifluoroacetic acid / 1.5 h
With
4-methyl-morpholine; sodium tetrahydroborate; iron; acetic acid; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate;
In
tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide;
2: Mitsunobu reaction;
DOI:10.1021/jm020475w
- Guidance literature:
-
Multi-step reaction with 7 steps
1: N-methylmorpholine / dioxane / 20 °C
2: diethyl azaodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 °C
3: Fe; aq. acetic acid / 1.5 h / 60 °C
4: N-methylmorpholine / dimethylformamide / 80 °C
5: ethanol / 5 h / 20 °C
6: 104 mg / sodium borohydride / ethanol / 20 °C
7: trifluoroacetic acid / 1.5 h
With
4-methyl-morpholine; sodium tetrahydroborate; iron; acetic acid; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate;
In
tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide;
2: Mitsunobu reaction;
DOI:10.1021/jm020475w
