tert-butyl 4-{5-[(1S)-1-acetoxyethyl]-1,2,4-oxadiazol-3-yl}-2-fluorobenzoate

Base Information

Chemical Name:tert-butyl 4-{5-[(1S)-1-acetoxyethyl]-1,2,4-oxadiazol-3-yl}-2-fluorobenzoate
CAS No.:1371591-82-0
Molecular Formula:C₁₇H₁₉FN₂O₅
Molecular Weight:350.347
Hs Code.:

Synonyms:tert-butyl 4-{5-[(1S)-1-acetoxyethyl]-1,2,4-oxadiazol-3-yl}-2-fluorobenzoate

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Chemical Property of tert-butyl 4-{5-[(1S)-1-acetoxyethyl]-1,2,4-oxadiazol-3-yl}-2-fluorobenzoate

Chemical Property:

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Technology Process of tert-butyl 4-{5-[(1S)-1-acetoxyethyl]-1,2,4-oxadiazol-3-yl}-2-fluorobenzoate

There total 3 articles about tert-butyl 4-{5-[(1S)-1-acetoxyethyl]-1,2,4-oxadiazol-3-yl}-2-fluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 535-17-1,3853-80-3,18668-00-3,6034-46-4
(S)-2-acetoxypropionic acid

: 1263483-74-4
tert-butyl 4-amino(hydroxyimino)methyl-2-fluorobenzoate

: 1371591-82-0
tert-butyl 4-{5-[(1S)-1-acetoxyethyl]-1,2,4-oxadiazol-3-yl}-2-fluorobenzoate

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; at 20 - 90 ℃;

Reference yield:

: 164149-28-4
4-cyano-2-fluorobenzoic acid

: 1371591-82-0
tert-butyl 4-{5-[(1S)-1-acetoxyethyl]-1,2,4-oxadiazol-3-yl}-2-fluorobenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; di-tert-butyl dicarbonate / tetrahydrofuran; tert-butyl alcohol / 3 h / 60 °C

2: hydroxylamine / tetrahydrofuran; ethanol / 2 h / 80 °C

3: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / N,N-dimethyl-formamide / 20 - 90 °C

With dmap; di-tert-butyl dicarbonate; hydroxylamine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 872018-02-5
tert-butyl 4-cyano-2-fluorobenzoate

: 1371591-82-0
tert-butyl 4-{5-[(1S)-1-acetoxyethyl]-1,2,4-oxadiazol-3-yl}-2-fluorobenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: hydroxylamine / tetrahydrofuran; ethanol / 2 h / 80 °C

2: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / N,N-dimethyl-formamide / 20 - 90 °C

With hydroxylamine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;