tert-butyl 2-fluoro-4-{5-[(1S)-1-hydroxyethyl]-1,2,4-oxadiazol-3-yl}benzoate

Base Information

Chemical Name:tert-butyl 2-fluoro-4-{5-[(1S)-1-hydroxyethyl]-1,2,4-oxadiazol-3-yl}benzoate
CAS No.:1371591-81-9
Molecular Formula:C₁₅H₁₇FN₂O₄
Molecular Weight:308.309
Hs Code.:

Synonyms:tert-butyl 2-fluoro-4-{5-[(1S)-1-hydroxyethyl]-1,2,4-oxadiazol-3-yl}benzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl 2-fluoro-4-{5-[(1S)-1-hydroxyethyl]-1,2,4-oxadiazol-3-yl}benzoate

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Technology Process of tert-butyl 2-fluoro-4-{5-[(1S)-1-hydroxyethyl]-1,2,4-oxadiazol-3-yl}benzoate

There total 5 articles about tert-butyl 2-fluoro-4-{5-[(1S)-1-hydroxyethyl]-1,2,4-oxadiazol-3-yl}benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 535-17-1,3853-80-3,18668-00-3,6034-46-4
(S)-2-acetoxypropionic acid

: 1263483-74-4
tert-butyl 4-amino(hydroxyimino)methyl-2-fluorobenzoate

: 1371591-81-9
tert-butyl 2-fluoro-4-{5-[(1S)-1-hydroxyethyl]-1,2,4-oxadiazol-3-yl}benzoate

Guidance literature:: (S)-2-acetoxypropionic acid; With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

tert-butyl 4-amino(hydroxyimino)methyl-2-fluorobenzoate; In N,N-dimethyl-formamide; at 90 ℃; for 3.16667h;

With potassium carbonate; In methanol;

Reference yield: 93.0%

: 1371591-82-0
tert-butyl 4-{5-[(1S)-1-acetoxyethyl]-1,2,4-oxadiazol-3-yl}-2-fluorobenzoate

: 1371591-81-9
tert-butyl 2-fluoro-4-{5-[(1S)-1-hydroxyethyl]-1,2,4-oxadiazol-3-yl}benzoate

Guidance literature:: With methanol; potassium carbonate; at 20 ℃; Cooling with ice;

Reference yield:

: 164149-28-4
4-cyano-2-fluorobenzoic acid

: 1371591-81-9
tert-butyl 2-fluoro-4-{5-[(1S)-1-hydroxyethyl]-1,2,4-oxadiazol-3-yl}benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: dmap; di-tert-butyl dicarbonate / tetrahydrofuran; tert-butyl alcohol / 3 h / 60 °C

2: hydroxylamine / tetrahydrofuran; ethanol / 2 h / 80 °C

3: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / N,N-dimethyl-formamide / 20 - 90 °C

4: methanol; potassium carbonate / 20 °C / Cooling with ice

With methanol; dmap; di-tert-butyl dicarbonate; hydroxylamine; potassium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; tert-butyl alcohol;