2-{3-[4-(2-ethoxycarbonyl-1-pyridin-3-yl-ethylcarbamoyl)-2-oxo-pyrrolidin-1-yl]-phenylimino}-dihydro-pyrimidine-1,3-dicarboxylic acid di-tert-butyl ester

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Chemical Name:2-{3-[4-(2-ethoxycarbonyl-1-pyridin-3-yl-ethylcarbamoyl)-2-oxo-pyrrolidin-1-yl]-phenylimino}-dihydro-pyrimidine-1,3-dicarboxylic acid di-tert-butyl ester
CAS No.:723284-68-2
Molecular Formula:C₃₅H₄₆N₆O₈
Molecular Weight:678.786
Hs Code.:

2-{3-[4-(2-ethoxycarbonyl-1-pyridin-3-yl-ethylcarbamoyl)-2-oxo-pyrrolidin-1-yl]-phenylimino}-dihydro-pyrimidine-1,3-dicarboxylic acid di-<i>tert</i>-butyl ester

Synonyms:2-{3-[4-(2-ethoxycarbonyl-1-pyridin-3-yl-ethylcarbamoyl)-2-oxo-pyrrolidin-1-yl]-phenylimino}-dihydro-pyrimidine-1,3-dicarboxylic acid di-tert-butyl ester

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Chemical Property of 2-{3-[4-(2-ethoxycarbonyl-1-pyridin-3-yl-ethylcarbamoyl)-2-oxo-pyrrolidin-1-yl]-phenylimino}-dihydro-pyrimidine-1,3-dicarboxylic acid di-tert-butyl ester

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Technology Process of 2-{3-[4-(2-ethoxycarbonyl-1-pyridin-3-yl-ethylcarbamoyl)-2-oxo-pyrrolidin-1-yl]-phenylimino}-dihydro-pyrimidine-1,3-dicarboxylic acid di-tert-butyl ester

There total 5 articles about 2-{3-[4-(2-ethoxycarbonyl-1-pyridin-3-yl-ethylcarbamoyl)-2-oxo-pyrrolidin-1-yl]-phenylimino}-dihydro-pyrimidine-1,3-dicarboxylic acid di-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 173300-85-1
N,N'-(di-tert-butoxycarbonyl)-3,4,5,6-tetrahydro-1H-2-pyrimidinethione

: 345296-38-0
ethyl 3-{(1-(3-aminophenyl)-5-oxopyrrolidin-3-yl)carbonylamino}-3-(pyridin-3-yl)-propanoate

: 723284-68-2
2-{3-[4-(2-ethoxycarbonyl-1-pyridin-3-yl-ethylcarbamoyl)-2-oxo-pyrrolidin-1-yl]-phenylimino}-dihydro-pyrimidine-1,3-dicarboxylic acid di-tert-butyl ester

Guidance literature:: With mercury dichloride; In N,N-dimethyl-formamide; for 16h;
DOI:10.1016/j.bmcl.2004.03.033

Reference yield:

: 97-65-4,25119-64-6
2-methylenesuccinic acid

: 723284-68-2
2-{3-[4-(2-ethoxycarbonyl-1-pyridin-3-yl-ethylcarbamoyl)-2-oxo-pyrrolidin-1-yl]-phenylimino}-dihydro-pyrimidine-1,3-dicarboxylic acid di-tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / 8 h / 110 °C

2: 90 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; HOBt; Et₃N / dimethylformamide / 8 h / 20 °C

3: 80 percent / Zn; aq. AcOH / tetrahydrofuran

4: 80 percent / HgCl₂ / dimethylformamide / 16 h

With benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; mercury dichloride; zinc; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2004.03.033

Reference yield:

: 345297-65-6
1-(3-nitro-phenyl)-5-oxo-pyrrolidine-3-carboxylic acid

: 723284-68-2
2-{3-[4-(2-ethoxycarbonyl-1-pyridin-3-yl-ethylcarbamoyl)-2-oxo-pyrrolidin-1-yl]-phenylimino}-dihydro-pyrimidine-1,3-dicarboxylic acid di-tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; HOBt; Et₃N / dimethylformamide / 8 h / 20 °C

2: 80 percent / Zn; aq. AcOH / tetrahydrofuran

3: 80 percent / HgCl₂ / dimethylformamide / 16 h

With benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; mercury dichloride; zinc; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2004.03.033