1-[4-(tert-Butyl-dimethyl-silanyloxy)-2,6-dihydroxy-3,5-dimethyl-phenyl]-2-methyl-butan-1-one

Base Information

• Chemical Name: 1-[4-(tert-Butyl-dimethyl-silanyloxy)-2,6-dihydroxy-3,5-dimethyl-phenyl]-2-methyl-butan-1-one
• CAS No.: 87035-86-7
• Molecular Formula: C₁₉H₃₂O₄Si
• Molecular Weight: 352.546

Synonyms:1-[4-(tert-Butyl-dimethyl-silanyloxy)-2,6-dihydroxy-3,5-dimethyl-phenyl]-2-methyl-butan-1-one

Chemical Property of 1-[4-(tert-Butyl-dimethyl-silanyloxy)-2,6-dihydroxy-3,5-dimethyl-phenyl]-2-methyl-butan-1-one

Chemical Property:

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Technology Process of 1-[4-(tert-Butyl-dimethyl-silanyloxy)-2,6-dihydroxy-3,5-dimethyl-phenyl]-2-methyl-butan-1-one

There total 2 articles about 1-[4-(tert-Butyl-dimethyl-silanyloxy)-2,6-dihydroxy-3,5-dimethyl-phenyl]-2-methyl-butan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

2.4.6-Tri-hydroxy-5-(α-methyl-butyryl)-m-xylol (65792-31-6) + tert-butyldimethylsilyl chloride (18162-48-6) → 1-[4-(tert-Butyl-dimethyl-silanyloxy)-2,6-dihydroxy-3,5-dimethyl-phenyl]-2-methyl-butan-1-one (87035-86-7)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

DOI:10.1016/S0040-4039(00)81973-5

Reference yield:

2,4-dimethylbenzene-1,3,5-triol (4463-02-9) → 1-[4-(tert-Butyl-dimethyl-silanyloxy)-2,6-dihydroxy-3,5-dimethyl-phenyl]-2-methyl-butan-1-one (87035-86-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / boron trifluoride / 4 h / 85 °C

2: 73 percent / imidazole / dimethylformamide / 3 h / 20 °C

With 1H-imidazole; boron trifluoride; In N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)81973-5

Reference yield: 92.0%

1-[4-(tert-Butyl-dimethyl-silanyloxy)-2,6-dihydroxy-3,5-dimethyl-phenyl]-2-methyl-butan-1-one (87035-86-7) + dimethyl sulfate (77-78-1) → 1-(4-tert-butyldimethylsilyloxy-2,6-dimethoxy-3,5-dimethylphenyl)-2-methylbutan-1-one (87035-87-8)

Guidance literature:

With potassium carbonate; In acetone; at 20 ℃; for 15h;

DOI:10.1016/S0040-4039(00)81973-5

upstream raw materials:

2.4.6-Tri-hydroxy-5-(α-methyl-butyryl)-m-xylol

tert-butyldimethylsilyl chloride

2,4-dimethylbenzene-1,3,5-triol

Downstream raw materials:

1-(4-tert-butyldimethylsilyloxy-2,6-dimethoxy-3,5-dimethylphenyl)-2-methylbutan-1-one

1-(4-hydroxy-2,6-dimethoxy-3,5-dimethylphenyl)-2-methylbutan-1-one

Acetic acid 2,4-dimethoxy-1,5-dimethyl-3-(2-methyl-butyryl)-6-oxo-cyclohexa-2,4-dienyl ester

5‐amino‐2,6‐dimethyl‐6‐hydroxy‐4‐(2‐methyl‐1‐oxobutyl)‐3‐methoxy‐2,4‐cyclohexadien‐1‐one

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