4463-02-9

Basic information

• Product Name: 2,4,6-TRIHYDROXY-1,3-DIMETHYL BENZENE
• Synonyms: 2,4,6-Trihydroxy-m-xylene;2,4-Dimethyl-1,3,5-benzenetriol;2,4,6-TRIHYDROXY-1,3-DIMETHYL BENZENE;2,4,6-TRIHYDROXY-3-XYLENE;2,4-dimethylphloroglucinol;m-Xylene-2,4,6-triol;2,4-dimethylbenzene-1,3,5-triol
• CAS NO: 4463-02-9
• Molecular Formula: C₈H₁₀O₃
• Molecular Weight: 154.16
• EINECS: 224-725-9
• Product Categories: Aromatic Hydrocarbons (substituted) & Derivatives
• Mol File: 4463-02-9.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 304.3 °C at 760 mmHg
• Flash Point: 151.9 °C
• Appearance: /
• Density: 1.314 g/cm³
• Vapor Pressure: 0.000489mmHg at 25°C
• Refractive Index: 1.626
• CAS DataBase Reference: 2,4,6-TRIHYDROXY-1,3-DIMETHYL BENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,6-TRIHYDROXY-1,3-DIMETHYL BENZENE(4463-02-9)
• EPA Substance Registry System: 2,4,6-TRIHYDROXY-1,3-DIMETHYL BENZENE(4463-02-9)

Safety Data

• Hazardous Substances Data: 4463-02-9(Hazardous Substances Data)

Usage

Uses

m-Xylene-2,4,6-triol is a reagent used to synthesize a series of flavanone derivatives that show anti-tumor activities.

InChI:InChI=1/C8H10O3/c1-4-6(9)3-7(10)5(2)8(4)11/h3,9-11H,1-2H3

Upstream product

• 82-08-6 rottlerin 
• 859074-35-4 2,4,6-trihydroxy-3,5-dimethyl-benzoic acid methyl ester 
• 94135-19-0 2,4-dimethyl-benzene-1,3,5-triyltriamine 
• 632-92-8 2,4-dimethyl-1,3,5-trinitrobenzene 
• 487-70-7 2,4,6-trihydroxybenzaldehyde 
• 88-03-9 2,4,6-trihydroxytoluene 
• 108-38-3 m-xylene 
• 4396-13-8 2,4-diformyl 2,4,6-trihydroxybenzene 
• 108-73-6 3,5-dihydroxyphenol 
• 3147-39-5 methyl 2,4,6-trihydroxybenzoate 
• 207924-64-9 1-tert-butyl-3,5-dimethyl-2,4,6-triaminobenzene 
• 7732-18-5 water 
• 74-88-4 methyl iodide 
• 94632-38-9 1,3-Dihydroxy-5-methoxy-2,4-dimethyl-benzol 

Downstream Products

• 13383-64-7 2,4,6-trihydroxy-3,5-dimethylbenzaldehyde 
• 27593-80-2 5,7-dihydroxy-6,8-dimethylflavanone 
• 95273-01-1 2,3-dihydro-5,7-dihydroxy-2-(4-methoxyphenyl)-6,8-dimethylchromen-4-one 
• 65792-31-6 2.4.6-Tri-hydroxy-5-(α-methyl-butyryl)-m-xylol 
• 22744-25-8 3,5-dimethyl-2,4,6-trihydroxybenzophenone 
• 95273-00-0 6,8-dimethyl-3’-methoxy-4’,5,7-trihydroxyflavanone 
• 95272-99-4 2-(3,4-dihydroxy-phenyl)-5,7-dihydroxy-6,8-dimethyl-chroman-4-one 
• 84633-27-2 Dimethylphlorobutyrophenone 
• 1402589-43-8 C₁₆H₁₆O₄ 
• 1402589-44-9 C₁₆H₁₅FO₄ 
• 1402589-45-0 C₁₆H₁₅ClO₄ 
• 1402589-46-1 C₁₇H₁₈O₅ 
• 1402589-48-3 C₁₆H₁₄Cl₂O₄ 
• 1402589-50-7 C₁₇H₁₈O₄ 

Relevant articles and documents

A Nouvel Route to Resorcinols

Hydroxylation of para-alkylated or 2,6-dialkylated phenols by hydrogen peroxide in SbF5-HF yields resorcinols, the electrophile reacting with the O-protonated substrate.

DIMETHYLCHALCONE DERIVATIVES AND PREPARATION METHOD THEREOF

The present invention relates to a dimethalcone (DMC) derivative and a method for producing the same. A compound according to an embodiment of the present invention is represented by chemical formula I: [Chemical Formula I]. In Formula I, R1, R2, and R3 are the same as or different from each other, R1 is a hydroxy group or a methoxy group, R2, and R3 are each independently hydrogen, deuterium, a nitro group, a hydroxyl group, a carbonyl group C1?C10, a nitro group, C1?C10 a hydroxyl group, an 'C2?C10 alkyloxy group', an aryloxy C2?C10 group, an aryloxy group, an alkylthioxy group, a silyl group, a boron group, an alkyl group or an C6?C20 aryl group. (C1?C10. The cycloalkyl group, alkenyl group, alkynyl group, aryl group, aralkyl group, aralkyl group, alkylaryl group, alkylamine group. The substituent may be substituted or unsubstituted with 1 or more substituents selected from the group consisting of an aralkylamine group, a heteroarylamine group, an arylamine group, an arylphosphine group, and a heterocyclic group.

Discovery of Anti-TNBC Agents Targeting PTP1B: Total Synthesis, Structure-Activity Relationship, in Vitro and in Vivo Investigations of Jamunones

Twenty-three natural jamunone analogues along with a series of jamunone-based derivatives were synthesized and evaluated for their inhibitory effects against breast cancer (BC) MDA-MB-231 and MCF-7 cells. The preliminary structure-activity relationship revealed that the length of aliphatic side chain and free phenolic hydroxyl group at the scaffold played a vital role in anti-BC activities and the methyl group on chromanone affected the selectivity of molecules against MDA-MB-231 and MCF-7 cells. Among them, jamunone M (JM) was screened as the most effective anti-triple-negative breast cancer (anti-TNBC) candidate with a high selectivity against BC cells over normal human cells. Mechanistic investigations indicated that JM could induce mitochondria-mediated apoptosis and cause G0/G1 phase arrest in BC cells. Furthermore, JM significantly restrained tumor growth in MDA-MB-231 xenograft mice without apparent toxicity. Interestingly, JM could downregulate phosphatidylinositide 3-kinase (PI3K)/Akt pathway by suppressing protein-tyrosine phosphatase 1B (PTP1B) expression. These findings revealed the potential of JM as an appealing therapeutic drug candidate for TNBC.