Technology Process of (R,E)-3-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidine-1-carbonyl)-2,8,8-trimethyl-5,10,14-trioxo-9,11,13-trioxa-4,6-diazaheptadec-15-en-17-oic acid
There total 11 articles about (R,E)-3-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidine-1-carbonyl)-2,8,8-trimethyl-5,10,14-trioxo-9,11,13-trioxa-4,6-diazaheptadec-15-en-17-oic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triethylamine;
In
N,N-dimethyl-formamide;
at 20 - 70 ℃;
for 20h;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: n-butyllithium / hexane; tetrahydrofuran / 1.5 h / -78 - -60 °C
1.2: 2 h / -78 - -60 °C
2.1: hydrogenchloride / 1,4-dioxane / 4 h / 20 °C
3.1: butanone; water / 20 °C / Reflux
4.1: sodium hydroxide / water
5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / benzotriazol-1-ol / dichloromethane / 0.5 h / 20 °C
5.2: 20 h / 20 °C
6.1: hydrogenchloride / 1,4-dioxane / 2.5 h / 20 °C
7.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C
7.2: 1 h
8.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C / Inert atmosphere; Reflux
9.1: pyridine / dichloromethane / 1.05 h / 20 °C
10.1: triethylamine / N,N-dimethyl-formamide / 20 h / 20 - 70 °C
With
pyridine; hydrogenchloride; n-butyllithium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide;
benzotriazol-1-ol;
In
tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; butanone;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: butanone; water / 20 °C / Reflux
2.1: sodium hydroxide / water
3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / benzotriazol-1-ol / dichloromethane / 0.5 h / 20 °C
3.2: 20 h / 20 °C
4.1: hydrogenchloride / 1,4-dioxane / 2.5 h / 20 °C
5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C
5.2: 1 h
6.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C / Inert atmosphere; Reflux
7.1: pyridine / dichloromethane / 1.05 h / 20 °C
8.1: triethylamine / N,N-dimethyl-formamide / 20 h / 20 - 70 °C
With
pyridine; hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide;
benzotriazol-1-ol;
In
1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; butanone;
