chloromethyl 1-(3-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)ureido)-2-methylpropan-2-yl carbonate

Base Information

Chemical Name:chloromethyl 1-(3-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)ureido)-2-methylpropan-2-yl carbonate
CAS No.:1285548-83-5
Molecular Formula:C₂₅H₃₇Cl₂N₃O₆
Molecular Weight:546.491
Hs Code.:

Synonyms:chloromethyl 1-(3-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)ureido)-2-methylpropan-2-yl carbonate

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Chemical Property of chloromethyl 1-(3-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)ureido)-2-methylpropan-2-yl carbonate

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Technology Process of chloromethyl 1-(3-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)ureido)-2-methylpropan-2-yl carbonate

There total 10 articles about chloromethyl 1-(3-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)ureido)-2-methylpropan-2-yl carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.4%

: 1202400-18-7
1-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)-3-(2-hydroxy-2-methylpropyl)urea

: 22128-62-7
carbonochloridic acid, chloromethyl ester

: 1285548-83-5
chloromethyl 1-(3-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)ureido)-2-methylpropan-2-yl carbonate

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 1.05h;

Reference yield:

: 324769-06-4
tert-butyl 3,3-dimethyl-4-oxopiperidine-1-carboxylate

: 1285548-83-5
chloromethyl 1-(3-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)ureido)-2-methylpropan-2-yl carbonate

Guidance literature:: Multi-step reaction with 9 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 1.5 h / -78 - -60 °C

1.2: 2 h / -78 - -60 °C

2.1: hydrogenchloride / 1,4-dioxane / 4 h / 20 °C

3.1: butanone; water / 20 °C / Reflux

4.1: sodium hydroxide / water

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / benzotriazol-1-ol / dichloromethane / 0.5 h / 20 °C

5.2: 20 h / 20 °C

6.1: hydrogenchloride / 1,4-dioxane / 2.5 h / 20 °C

7.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

7.2: 1 h

8.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C / Inert atmosphere; Reflux

9.1: pyridine / dichloromethane / 1.05 h / 20 °C

With pyridine; hydrogenchloride; n-butyllithium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; benzotriazol-1-ol; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; water; acetonitrile; butanone;

Reference yield:

: 475085-56-4
4-(4-chloro-phenyl)-4-hydroxy-3,3-dimethyl-piperidine-1-carboxylic acid tert-butyl ester

: 1285548-83-5
chloromethyl 1-(3-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)ureido)-2-methylpropan-2-yl carbonate

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogenchloride / 1,4-dioxane / 4 h / 20 °C

2.1: butanone; water / 20 °C / Reflux

3.1: sodium hydroxide / water

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / benzotriazol-1-ol / dichloromethane / 0.5 h / 20 °C

4.2: 20 h / 20 °C

5.1: hydrogenchloride / 1,4-dioxane / 2.5 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

6.2: 1 h

7.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C / Inert atmosphere; Reflux

8.1: pyridine / dichloromethane / 1.05 h / 20 °C

With pyridine; hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; benzotriazol-1-ol; In 1,4-dioxane; dichloromethane; water; acetonitrile; butanone;