(4R,5R)-(+)-5-ethyl-1-(4-hydroxy-3-methoxyphenethyl)-2-oxo-4-piperidineacetic acid

Base Information

Chemical Name:(4R,5R)-(+)-5-ethyl-1-(4-hydroxy-3-methoxyphenethyl)-2-oxo-4-piperidineacetic acid
CAS No.:82260-60-4
Molecular Formula:C₁₈H₂₅NO₅
Molecular Weight:335.4
Hs Code.:

Synonyms:(4R,5R)-(+)-5-ethyl-1-(4-hydroxy-3-methoxyphenethyl)-2-oxo-4-piperidineacetic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4R,5R)-(+)-5-ethyl-1-(4-hydroxy-3-methoxyphenethyl)-2-oxo-4-piperidineacetic acid

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Technology Process of (4R,5R)-(+)-5-ethyl-1-(4-hydroxy-3-methoxyphenethyl)-2-oxo-4-piperidineacetic acid

There total 1 articles about (4R,5R)-(+)-5-ethyl-1-(4-hydroxy-3-methoxyphenethyl)-2-oxo-4-piperidineacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 82260-59-1
(4S,5R)-(-)-5-ethyl-1-(4-hydroxy-3-methoxyphenethyl)-2-oxo-4-piperidineacetic acid

: 82260-60-4
(4R,5R)-(+)-5-ethyl-1-(4-hydroxy-3-methoxyphenethyl)-2-oxo-4-piperidineacetic acid

Guidance literature:: In neat (no solvent); at 180 ℃; for 1.5h;

Reference yield: 99.0%

: 64-17-5
ethanol

: 82260-60-4
(4R,5R)-(+)-5-ethyl-1-(4-hydroxy-3-methoxyphenethyl)-2-oxo-4-piperidineacetic acid

: 82310-90-5
(4R,5R)-(+)-5-ethyl-1-(4-hydroxy-3-methoxyphenethyl)-2-oxo-4-piperidineacetic acid ethyl ester

Guidance literature:: With hydrogenchloride; at 15 ℃; for 24h;

Reference yield:

: 82260-60-4
(4R,5R)-(+)-5-ethyl-1-(4-hydroxy-3-methoxyphenethyl)-2-oxo-4-piperidineacetic acid

: 82310-54-1
(2R,3R,11bS)-(-)-10-benzyloxy-3-ethyl-1,3,4,6,7,11b-hexahydro-9-methoxy-2H-benzo quinolizine-2-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / HCl / 24 h / 15 °C

2: 96 percent / K₂CO₃ / acetone / 26 h / Heating

3: POCl₃ / toluene / 1.5 h / Heating

4: H₂ / Pt / ethanol / 1 h / 760 Torr / Ambient temperature

With hydrogenchloride; hydrogen; potassium carbonate; trichlorophosphate; platinum; In ethanol; acetone; toluene;