2-(3,5-dichloropyridin-4-yl)-1-(2,4-dimethoxy-3-hydroxyphenyl)ethanone

Base Information

Chemical Name:2-(3,5-dichloropyridin-4-yl)-1-(2,4-dimethoxy-3-hydroxyphenyl)ethanone
CAS No.:1035571-28-8
Molecular Formula:C₁₅H₁₃Cl₂NO₄
Molecular Weight:342.179
Hs Code.:

Synonyms:2-(3,5-dichloropyridin-4-yl)-1-(2,4-dimethoxy-3-hydroxyphenyl)ethanone

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Chemical Property of 2-(3,5-dichloropyridin-4-yl)-1-(2,4-dimethoxy-3-hydroxyphenyl)ethanone

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Technology Process of 2-(3,5-dichloropyridin-4-yl)-1-(2,4-dimethoxy-3-hydroxyphenyl)ethanone

There total 4 articles about 2-(3,5-dichloropyridin-4-yl)-1-(2,4-dimethoxy-3-hydroxyphenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 208043-53-2
[2-(3,5-Dichloro-pyridin-4-yl)-1-oxoethyl]-2,3-dihydroxy-4-methoxybenzene

: 74-88-4
methyl iodide

: 1035571-28-8
2-(3,5-dichloropyridin-4-yl)-1-(2,4-dimethoxy-3-hydroxyphenyl)ethanone

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1021/jm500378a

Reference yield:

: 6395-18-2
methyl 2,3,4-trimethoxybenzoate

: 1035571-28-8
2-(3,5-dichloropyridin-4-yl)-1-(2,4-dimethoxy-3-hydroxyphenyl)ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hexamethyldisilazane / tetrahydrofuran / 1.5 h / 0 °C

2: acetic acid; hydrogen iodide / 18 h / 80 °C

3: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

With hydrogen iodide; potassium carbonate; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm500378a

Reference yield:

: 100868-46-0
3,5-dichloro-4-picoline

: 1035571-28-8
2-(3,5-dichloropyridin-4-yl)-1-(2,4-dimethoxy-3-hydroxyphenyl)ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hexamethyldisilazane / tetrahydrofuran / 1.5 h / 0 °C

2: acetic acid; hydrogen iodide / 18 h / 80 °C

3: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

With hydrogen iodide; potassium carbonate; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm500378a