5100-34-5

Usage

Uses

Used in Pharmaceutical Industry:
ETHYL 3-ISOCYANATOPROPIONATE is used as a chemical intermediate for the synthesis of complex organic molecules. It plays a crucial role in the production of 3-[1-(2-dimethylamino-ethylcarbamoyl)-5,6-dimethyl-6H-pyrido[4,3-b]carbazol-9-yloxycarbonylamino]-propionic acid ethyl ester with 9-hydroxy-5,6-dimethyl-6H-pyrido[4,3-b]carbazole-1-carboxylic acid (2-dimethylamino-ethyl)-amide. ETHYL 3-ISOCYANATOPROPIONATE has potential applications in the development of new drugs and therapeutic agents, contributing to advancements in the pharmaceutical field.

InChI:InChI=1/C6H9NO3/c1-2-10-6(9)3-4-7-5-8/h2-4H2,1H3

Upstream product

• 924-73-2 3-amino-propionic acid ethyl ester 
• 503-38-8 trichloromethyl chloroformate 
• 75-44-5 phosgene 
• 4244-84-2 ethyl β-alaninate hydrochloride 
• 7364-55-8 N-trimethylsilanyl-β-alanine ethyl ester 
• 32315-10-9 bis(trichloromethyl) carbonate 

Downstream Products

• 109257-54-7 N-(3-phenyl-hydrazinocarbonyl)-β-alanine ethyl ester 
• 92033-49-3 N-benzylcarbamoyl-β-alanine ethyl ester 
• 626255-56-9 (E,E)-3-{3-[4-{4-(4-methyl-2,5-bis[(S)-2-methylbutoxy]styryl)-2,5-bis[(S)-2-methylbutoxy]styryl}phenyl]ureido}propionic acid ethyl ester 
• 626255-50-3 (E,E)-3-[6-{4-{4-(4-methyl-2,5-bis[(S)-2-methylbutoxy]styryl)-2,5-bis[(S)-2-methylbutoxy]styryl}-2,5-bis[(S)-2-methylbutoxy]benzoylamino}hexylureido]propionic acid ethyl ester 
• 685544-36-9 3-{[2-(4-cyanophenyl)-1-oxo-2,8-diazaspiro[4.5]decane-8-carbonyl]amino}propionic acid ethyl ester 
• 671777-33-6 ethyl N-{[(3-IODOPHENYL) AMINO]CARBONVL}-?-ALANINATE 
• 1021923-75-0 C₂₀H₁₈FN₃O₅ 
• 300354-60-3 3-{3-[3-cyclopentyl-2-(3,4-dichlorophenyl)propionyl]ureido}propionic acid ethyl ester 
• 685544-95-0 3-({2-[4-(N-hydroxycarbamimidoyl)phenyl]-1-oxo-2,8-diazaspiro[4.5]decane-8-carbonyl}amino)propionic acid ethyl ester 
• 685544-37-0 3-{[2-(4-carbamimidoylphenyl)-1-oxo-2,8-diazaspiro[4.5]decane-8-carbonyl]amino}propionic acid ethyl ester 

Relevant academic research and scientific papers

TETRACYCLIC AUTOTAXIN INHIBITORS

Described herein are compounds that are autotaxin inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with autotaxin activity.

Organosilicon synthesis of isocyanates: III. Synthesis of aliphatic, carbocyclic, aromatic, and alkylaromatic isocyanatocatboxylic acid esters

A series of aminoacid esters was prepared by treating the aminoacid suspensions in ethanol with thionyl chloride. Best conversion of aminoacid esters to corresponding isocyanates was achieved in the case of aromatic and carbocyclic aminoesters by phosgeneation of their N-silyl derivatives, and in the case of aliphatic and alkylaromatic aminoesters by phosgeneation of O-silyl or N,O-bissilylurethanes on their basis. In the last case additional step of esterification of the by-products isocyanatoalkylcarboxylic acid chlorides is required after phosgeneation. Unusual generation of cynnamates and intramolecular N→O-migration of trimethylsilyl group in the solutions of silylated alkylaromatic β-aminoacid esters were found. Pleiades Publishing, Inc., 2006.

Cyclic urea derivatives, pharmaceutical compositions containing these compounds and processes for preparing them

The invention relates to cyclic urea derivatives of general formula STR1 wherein Ra, Rb, X and Y are as defined herein, pharmaceutical compositions containing the derivatives and processes for preparing them.

Cyclic urea derivatives, pharmaceutical compositions containing these compounds and methods of using the same

The invention relates to cyclic urea derivatives of general formula STR1 wherein Ra, Rb, X and Y are as defined herein, pharmaceutical compositions containing the derivatives and processes for preparing them.