2-((3-(4-chlorophenyl)-1-(2-(diethylamino)ethyl)-1H-pyrazol-5-yl)methoxy)ethanol

Base Information

Chemical Name:2-((3-(4-chlorophenyl)-1-(2-(diethylamino)ethyl)-1H-pyrazol-5-yl)methoxy)ethanol
CAS No.:1357158-09-8
Molecular Formula:C₁₈H₂₆ClN₃O₂
Molecular Weight:351.876
Hs Code.:

Synonyms:2-((3-(4-chlorophenyl)-1-(2-(diethylamino)ethyl)-1H-pyrazol-5-yl)methoxy)ethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-((3-(4-chlorophenyl)-1-(2-(diethylamino)ethyl)-1H-pyrazol-5-yl)methoxy)ethanol

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Technology Process of 2-((3-(4-chlorophenyl)-1-(2-(diethylamino)ethyl)-1H-pyrazol-5-yl)methoxy)ethanol

There total 7 articles about 2-((3-(4-chlorophenyl)-1-(2-(diethylamino)ethyl)-1H-pyrazol-5-yl)methoxy)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1357158-04-3
tert-butyl 2-((3-(4-chlorophenyl)-1-(2-(diethylamino)ethyl)-1H-pyrazol-5-yl)methoxy)acetate

: 1357158-09-8
2-((3-(4-chlorophenyl)-1-(2-(diethylamino)ethyl)-1H-pyrazol-5-yl)methoxy)ethanol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1002/cjoc.201180354

Reference yield:

: 938182-43-5,595610-40-5
5-(4-chloro-phenyl)-2H-pyrazole-3-carboxylic acid ethyl ester

: 1357158-09-8
2-((3-(4-chlorophenyl)-1-(2-(diethylamino)ethyl)-1H-pyrazol-5-yl)methoxy)ethanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate; potassium iodide / acetonitrile / 3.17 h / 20 °C / Reflux

2.1: potassium carbonate; potassium iodide / acetonitrile / 5.17 h / 20 °C / Reflux

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 20 °C / Cooling with ice

4.1: potassium / Inert atmosphere

4.2: 0.17 h / Inert atmosphere

4.3: 3 h / Inert atmosphere; Reflux

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 20 °C

With lithium aluminium tetrahydride; potassium; potassium carbonate; potassium iodide; In tetrahydrofuran; acetonitrile;
DOI:10.1002/cjoc.201180354

Reference yield:

: 1101861-37-3
ethyl 3-(4-chlorophenyl)-1-(2-bromoethyl)-1H-pyrazole-5-carboxylate

: 1357158-09-8
2-((3-(4-chlorophenyl)-1-(2-(diethylamino)ethyl)-1H-pyrazol-5-yl)methoxy)ethanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate; potassium iodide / acetonitrile / 5.17 h / 20 °C / Reflux

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 20 °C / Cooling with ice

3.1: potassium / Inert atmosphere

3.2: 0.17 h / Inert atmosphere

3.3: 3 h / Inert atmosphere; Reflux

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 20 °C

With lithium aluminium tetrahydride; potassium; potassium carbonate; potassium iodide; In tetrahydrofuran; acetonitrile;
DOI:10.1002/cjoc.201180354